与日本慢性便秘患者稳定治疗相关的临床因素。
Clinical factors associated with stable treatment of chronic constipation in Japanese patients.
机构信息
Department of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Department of Gastrointestinal Endoscopy and Medicine, Hiroshima University Hospital, Hiroshima, Japan.
出版信息
BMC Gastroenterol. 2024 Jan 29;24(1):52. doi: 10.1186/s12876-024-03140-y.
BACKGROUND/AIMS: Chronic constipation (CC) is one of the most common gastrointestinal disorders in the general population. Although there are many treatment options, achieving a stable treatment for CC remains one of the challenges in clinical practice. This study aimed to evaluate the clinical factors associated with stable treatment for CC in Japanese patients.
METHODS
A retrospective, cross-sectional, and multicenter study was carried out. Patients were eligible for inclusion if they fulfilled the Rome IV criteria for diagnosing CC and had been treated for at least one and a half years. Patients with up to two prescription modifications for CC in one year were defined as the stable treatment group, whereas those with three or more prescription changes were defined as the unstable treatment group. Univariate and multivariate analyses were carried out to identify factors associated with CC.
RESULTS
A total of 114 patients have been recruited. There were 82 patients (77.0%) in the stable treatment group and 32 patients (23.0%) in the unstable treatment group. Based on multivariate likelihood analysis, only using acid-suppressive drugs contributed to stability treatment in CC patients (odds ratio: 2.81, 95% confidence interval: 1.12-7.08, p = 0.03).
CONCLUSION
Administration of acid-suppressive drugs was the only factor related to the stability of CC treatment. Further studies are needed to validate the results as well as clarify the causes.
背景/目的：慢性便秘（CC）是普通人群中最常见的胃肠道疾病之一。尽管有许多治疗选择，但在临床实践中，实现 CC 的稳定治疗仍然是一个挑战。本研究旨在评估与日本患者 CC 稳定治疗相关的临床因素。
方法
进行了一项回顾性、横断面、多中心研究。如果患者符合罗马 IV 标准诊断为 CC 且已接受至少一年半的治疗，则有资格纳入研究。在一年内将 CC 的处方修改次数限制在两次以下的患者被定义为稳定治疗组，而将处方修改次数为三次或更多的患者定义为不稳定治疗组。进行单变量和多变量分析以确定与 CC 相关的因素。
结果
共招募了 114 名患者。稳定治疗组 82 例（77.0%），不稳定治疗组 32 例（23.0%）。基于多变量似然分析，仅使用酸抑制药物有助于 CC 患者的稳定治疗（优势比：2.81，95%置信区间：1.12-7.08，p=0.03）。
结论
酸抑制药物的使用是与 CC 治疗稳定性相关的唯一因素。需要进一步的研究来验证结果并阐明原因。
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