Department of Hepatopancreatobiliary Surgery, Shaoxing People's Hospital, Shaoxing, Zhejiang, China.
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
World J Surg Oncol. 2024 Jan 30;22(1):38. doi: 10.1186/s12957-024-03310-y.
Sarcopenia is associated with poor outcomes in many malignancies. However, the relationship between sarcopenia and the prognosis of pancreatic cancer has not been well understood. The aim of this meta-analysis was to identify the prognostic value of preoperative sarcopenia in patients with pancreatic cancer after curative-intent surgery.
Database from PubMed, Embase, and Web of Science were searched from its inception to July 2023. The primary outcomes were overall survival (OS), progression-free survival (PFS), and the incidence of major complications. The hazard ratio (HR), odds ratio (OR), and 95% confidence intervals (CIs) were used to assess the relationship between preoperative sarcopenia and the prognosis of patients with pancreatic cancer. All statistical analyses were conducted by Review Manager 5.3 and STATA 17.0 software.
A total of 23 retrospective studies involving 5888 patients were included in this meta-analysis. The pooled results demonstrated that sarcopenia was significantly associated with worse OS (HR = 1.53, P < 0.00001) and PFS (HR = 1.55, P < 0.00001). However, this association was not obvious in regard to the incidence of major complications (OR = 1.33, P = 0.11).
Preoperative sarcopenia was preliminarily proved to be associated with the terrible prognosis of pancreatic cancer after surgery. However, this relationship needs to be further validated in more prospective studies.
肌肉减少症与多种恶性肿瘤的不良结局相关。然而，肌肉减少症与胰腺癌预后之间的关系尚未得到充分了解。本荟萃分析的目的是确定术前肌肉减少症对接受根治性手术治疗的胰腺癌患者的预后价值。
从 PubMed、Embase 和 Web of Science 数据库中检索了从其建立到 2023 年 7 月的数据。主要结局指标为总生存期（OS）、无进展生存期（PFS）和主要并发症的发生率。使用风险比（HR）、优势比（OR）和 95%置信区间（CI）来评估术前肌肉减少症与胰腺癌患者预后之间的关系。所有统计分析均使用 Review Manager 5.3 和 STATA 17.0 软件进行。
本荟萃分析共纳入 23 项回顾性研究，涉及 5888 例患者。汇总结果表明，肌肉减少症与较差的 OS（HR=1.53，P<0.00001）和 PFS（HR=1.55，P<0.00001）显著相关。然而，在主要并发症的发生率方面，这种相关性并不明显（OR=1.33，P=0.11）。
术前肌肉减少症初步证明与手术后胰腺癌的不良预后相关。然而，这一关系需要在更多的前瞻性研究中进一步验证。
