Ryan A F, Schwartz I R
Brain Res. 1986 Dec 10;399(2):399-403. doi: 10.1016/0006-8993(86)91536-2.
[3H]Nipecotic acid was shown to be preferentially accumulated by the same cochlear structures which selectively accumulate [3H]gamma-aminobutyric acid ([3H]-GABA), including the terminals of a subset of olivocochlear neurons. With both amino acids, olivocochlear fibers selectively transported label in a retrograde direction, from cochlea to brainstem. However, only [3H]nipecotic acid produced dense labeling, and labeling of cell bodies in the superior olive, presumably because it is metabolized very slowly. Nipecotic acid appears to provide a selective retrograde tracer, specific to neurons whose terminals exhibit preferential GABA uptake.
[3H]哌啶酸被证明优先聚集在与选择性积累[3H]γ-氨基丁酸（[3H]-GABA）相同的耳蜗结构中，包括一部分橄榄耳蜗神经元的终末。对于这两种氨基酸，橄榄耳蜗纤维都能选择性地将标记物逆向运输，即从耳蜗到脑干。然而，只有[3H]哌啶酸产生密集标记，以及在上橄榄核中的细胞体标记，推测这是因为它代谢非常缓慢。哌啶酸似乎提供了一种选择性逆向示踪剂，对其终末表现出优先摄取GABA的神经元具有特异性。
