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大鼠外侧橄榄耳蜗神经元对[3H]-GABA的逆向转运

Retrograde transport of [3H]-GABA by lateral olivocochlear neurons in the rat.

作者信息

Schwarz D W, Schwarz I E, Hu K, Vincent S R

机构信息

Dept. of Physiology, University of British Columbia, Vancouver, Canada.

出版信息

Hear Res. 1988 Jan;32(1):97-102. doi: 10.1016/0378-5955(88)90150-5.

DOI:10.1016/0378-5955(88)90150-5
PMID:2832358
Abstract

Injection of [3H]-gamma aminobutyric acid (GABA) into the perilymphatic space of the rat's inner ear resulted in retrograde labeling of a portion of the small efferent olivocochlear neurons within the lateral superior olivary nucleus (LSO). These cells were of similar size as LSO neurons stained immunohistochemically with antibodies to the GABA synthesizing enzyme glutamic acid decarboxylase (GAD). They were of fusiform shape, but smaller than principal LSO cells, which did not stain for GAD and did not accumulate [3H]-GABA. Other efferent cochlear and vestibular neurons were not labeled.

摘要

将[3H] -γ-氨基丁酸(GABA)注入大鼠内耳的外淋巴间隙,导致外侧上橄榄核(LSO)内一部分小的传出橄榄耳蜗神经元出现逆行标记。这些细胞的大小与用GABA合成酶谷氨酸脱羧酶(GAD)抗体进行免疫组织化学染色的LSO神经元相似。它们呈梭形,但比主要的LSO细胞小,主要的LSO细胞不表达GAD且不摄取[3H] -GABA。其他传出性耳蜗和前庭神经元未被标记。

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