Department of Neurology, Affiliated Hospital of Nantong University, Medical School of Nantong University, 226001 Nantong, Jiangsu, China.
Department of Neurology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, 214023 Wuxi, Jiangsu, China.
J Integr Neurosci. 2024 Jan 16;23(1):15. doi: 10.31083/j.jin2301015.
The utilization of assisted reproductive technologies (ART) is on the rise, resulting in a growing population of ART-conceived offspring. The health concerns of this unique population have attracted significant attention. During ART procedures, gametes and early-stage embryos are exposed to various non-physiological conditions, such as manipulation, culture media, and cryopreservation, which may disrupt embryonic development and potentially impact the health of offspring. Notably, the potential impact of ART on neurodevelopment and its association with an increased risk of neurodevelopmental disorders (NDD) later in life remains a subject of debate. This review aims to summarize the current research advancements concerning the effects of ART on neurodevelopment, specifically focusing on the evidence of the relationship between ART, epigenetic modifications, and NDD, including autism spectrum disorder, intellectual disability, attention deficit hyperactivity disorder, and cerebral palsy. Future studies should prioritize large sample sizes, rigorous adjustment for confounding factors, and the use of interdisciplinary approaches to effectively monitor the neurodevelopmental outcomes of ART-conceived children.
辅助生殖技术（ART）的应用呈上升趋势，由此产生的 ART 受孕后代的数量也在不断增加。这一独特人群的健康问题引起了广泛关注。在 ART 过程中，配子和早期胚胎会暴露于各种非生理条件下，如操作、培养液和冷冻保存等，这些因素可能会干扰胚胎发育，并可能对后代的健康产生影响。值得注意的是，ART 对神经发育的潜在影响及其与神经发育障碍（NDD）风险增加之间的关联，仍然是一个有争议的话题。本综述旨在总结目前关于 ART 对神经发育影响的研究进展，特别关注 ART、表观遗传修饰与 NDD 之间关系的证据，包括自闭症谱系障碍、智力残疾、注意缺陷多动障碍和脑瘫。未来的研究应优先考虑大样本量、严格调整混杂因素，并采用跨学科方法，以有效监测 ART 受孕儿童的神经发育结局。
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