Bergh Christina, Wennerholm Ulla-Britt
Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
Reproductive Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Ups J Med Sci. 2020 May;125(2):152-157. doi: 10.1080/03009734.2020.1729904. Epub 2020 Feb 26.
The aim of this narrative review is to summarize the present knowledge on long-term outcome of children born after assisted reproductive technologies (ART). The main outcomes covered are neurodevelopment including cerebral palsy, cognitive development, attention deficit hyperactivity disorder and autism spectrum disease, growth, cardiovascular function, diabetes type 1, asthma, malignancies, and reproductive health. Results have mainly been obtained from systematic reviews/meta-analyses and large registry studies. It has been shown that children born after ART, when restricted to singletons, have a similar outcome for many health conditions as their spontaneously conceived peers. For some outcomes, particularly cardiovascular function and diabetes, studies show some higher risk for ART singletons or subgroup of ART singletons. The fast introduction of new ART techniques emphasizes the importance of continuous surveillance of children born after ART.
本叙述性综述的目的是总结目前关于辅助生殖技术（ART）后出生儿童长期结局的知识。涵盖的主要结局包括神经发育，如脑瘫、认知发育、注意力缺陷多动障碍和自闭症谱系疾病、生长、心血管功能、1型糖尿病、哮喘、恶性肿瘤和生殖健康。结果主要来自系统评价/荟萃分析和大型登记研究。研究表明，ART后出生的儿童（仅限于单胎）在许多健康状况方面与自然受孕的同龄人结局相似。对于某些结局，特别是心血管功能和糖尿病，研究表明ART单胎或ART单胎亚组存在一些更高的风险。新ART技术的快速引入凸显了持续监测ART后出生儿童的重要性。
