Menon M K, Lloyd R L
Psychopharmacology Research Laboratory, Veterans Administration Medical Center, Sepulveda, CA 91343.
Psychopharmacology (Berl). 1989;99(4):497-500. doi: 10.1007/BF00589898.
Ethanol (2.95 g/kg, IP) eliminated the righting reflex and induced vigorous tongue clonus spontaneously or following tactile tongue stimulation in Fischer F344 rats. Responses normally lasted 30-60 min, and was reinstated by tactile stimulation in those cases where it subsided quickly. Sub-hypnotic (1.95 g/kg) or high (3.95 g/kg) doses failed to elicit clonus, even after tactile stimulation. A lipophilic alpha 1-adrenergic agonist (St 587) promptly initiated tongue clonus in rats treated with a 3.95 g/kg dose of ethanol. Prazosin, a selective alpha 1-adrenergic antagonist, blocked clonus, while the dopamine selective antagonist pimozide failed to modify this response. We infer an alpha 1-adrenergic effect in which norepinephrine is released by ethanol.
在Fischer F344大鼠中，腹腔注射乙醇（2.95克/千克）可消除翻正反射，并自发地或在触觉刺激舌头后诱发强烈的舌阵挛。反应通常持续30 - 60分钟，在那些迅速消退的情况下，通过触觉刺激可恢复。亚催眠剂量（1.95克/千克）或高剂量（3.95克/千克）即使在触觉刺激后也未能引发阵挛。一种亲脂性α1肾上腺素能激动剂（St 587）能迅速在接受3.95克/千克乙醇剂量治疗的大鼠中引发舌阵挛。哌唑嗪，一种选择性α1肾上腺素能拮抗剂，可阻断阵挛，而多巴胺选择性拮抗剂匹莫齐特未能改变这种反应。我们推断存在一种α1肾上腺素能效应，即乙醇释放去甲肾上腺素。
