Magistretti P J, Hof P R, Celio M R
Brain Res. 1987 Feb 10;403(1):181-5. doi: 10.1016/0006-8993(87)90142-9.
The glycogenolytic action of norepinephrine (NE) was examined in the tottering mouse, a spontaneously epileptic mutant which presents a noradrenergic hyperinnervation of various CNS areas, including the cerebral cortex. The potency and efficacy of NE in promoting glycogenolysis were markedly decreased in cerebral cortical slices prepared from homozygous tottering (tg/tg) when compared to control C57BL/6j (+/+) mice, indicating a sub-sensitive response to a cellular action of NE. The metabolic nature of this adaptive change suggests that an impaired capacity of NE in mobilizing energy substrates may be related to the expression of the epileptic symptomatology in this mutant.
研究了去甲肾上腺素（NE）在蹒跚小鼠中的糖原分解作用。蹒跚小鼠是一种自发性癫痫突变体，其包括大脑皮层在内的各个中枢神经系统区域存在去甲肾上腺素能超神经支配。与对照C57BL/6j（+/+）小鼠相比，从纯合蹒跚（tg/tg）小鼠制备的大脑皮层切片中，NE促进糖原分解的效力和效能显著降低，表明对NE的细胞作用存在亚敏感反应。这种适应性变化的代谢性质表明，NE动员能量底物的能力受损可能与该突变体癫痫症状的表达有关。
