Magistretti P J, Morrison J H, Shoemaker W J, Bloom F E
Brain Res. 1983 Feb 14;261(1):159-62. doi: 10.1016/0006-8993(83)91297-0.
The effects of norepinephrine (NE) on in vitro [3H]glycogenolysis were assessed in slices of cerebral cortex from mice whose cortical noradrenergic innervation had been severely reduced by intracisternal 6-hydroxydopamine (6-OHDA) injections. A supersensitive response to NE was observed, as demonstrated by a decrease in the EC50 of the catecholamine in the lesioned mice from 533 +/- 88 nM to 39.3 +/- 7.9 nM. This supersensitive response, observed two weeks after the lesion, was post-synaptic since isoproterenol, a beta-adrenergic agonist not accumulated by pre-synaptic uptake mechanisms, also gave an equally supersensitive response.
通过脑池内注射6-羟基多巴胺（6-OHDA）使小鼠大脑皮质去甲肾上腺素能神经支配严重减少，在此基础上评估去甲肾上腺素（NE）对体外[3H]糖原分解的影响。结果观察到对NE的超敏反应，损伤小鼠体内儿茶酚胺的半数有效浓度（EC50）从533±88 nM降至39.3±7.9 nM，即表明了这一点。损伤两周后观察到的这种超敏反应是突触后反应，因为异丙肾上腺素（一种不通过突触前摄取机制蓄积的β-肾上腺素能激动剂）也产生了同样的超敏反应。
