Fan Xuanze, Zhang Aohua, Zheng Qingli, Li Pengcui, Wang Yanqin, He Liming, Xue Yanru, Chen Weiyi, Wu Xiaogang, Zhao Yongwang, Wang Yonghong
College of Biomedical Engineering, Taiyuan University of Technology, Taiyuan, China.
Shanxi Provincial Key Laboratory for Repair of Bone and Soft Tissue Injury, Taiyuan, China.
Front Bioeng Biotechnol. 2024 Jan 15;11:1323266. doi: 10.3389/fbioe.2023.1323266. eCollection 2023.
The prevention, control and treatment of cerebral aneurysm (CA) has become a common concern of human society, and by simulating the biomechanical environment of CA using finite element analysis (FEA), the risk of aneurysm rupture can be predicted and evaluated. The target models of the current study are mainly idealized single-layer linear elastic cerebral aneurysm models, which do not take into account the effects of the vessel wall structure, material constitution, and structure of the real CA model on the mechanical parameters. This study proposes a reconstruction method for patient-specific trilaminar CA structural modeling. Using two-way fluid-structure interaction (FSI), we comparatively analyzed the effects of the differences between linear and hyperelastic materials and three-layer and single-layer membrane structures on various hemodynamic parameters of the CA model. It was found that the numerical effects of the different CA membrane structures and material constitution on the stresses and wall deformations were obvious, but does not affect the change in its distribution pattern and had little effect on the blood flow patterns. For the same material constitution, the stress of the three-layer membrane structure were more than 10.1% larger than that of the single-layer membrane structure. For the same membrane structure, the stress of the hyperelastic material were more than 5.4% larger than that of the linear elastic material, and the displacement of the hyperelastic material is smaller than that of the linear elastic material by about 20%. And the maximum value of stress occurred in the media, and the maximum displacement occurred in the intima. In addition, the upper region of the tumor is the maximum rupture risk region for CA, and the neck of the tumor and the bifurcation of the artery are also the sub-rupture risk regions to focus on. This study can provide data support for the selection of model materials for CA simulation and analysis, as well as a theoretical basis for clinical studies and subsequent research methods.
脑动脉瘤（CA）的预防、控制和治疗已成为人类社会共同关注的问题，通过有限元分析（FEA）模拟CA的生物力学环境，可以预测和评估动脉瘤破裂的风险。目前研究的目标模型主要是理想化的单层线性弹性脑动脉瘤模型，没有考虑血管壁结构、材料组成以及真实CA模型的结构对力学参数的影响。本研究提出了一种针对患者特异性三层CA结构建模的重建方法。利用双向流固耦合（FSI），我们比较分析了线性和超弹性材料以及三层和单层膜结构之间的差异对CA模型各种血流动力学参数的影响。结果发现，不同的CA膜结构和材料组成对应力和壁变形的数值影响明显，但不影响其分布模式的变化，对血流模式影响较小。对于相同的材料组成，三层膜结构的应力比单层膜结构大10.1%以上。对于相同的膜结构，超弹性材料的应力比线性弹性材料大5.4%以上，且超弹性材料的位移比线性弹性材料小约20%。应力最大值出现在中膜，最大位移出现在内膜。此外，瘤体上部是CA的最大破裂风险区域，瘤颈和动脉分叉处也是需要关注的次破裂风险区域。本研究可为CA模拟分析模型材料的选择提供数据支持，也可为临床研究及后续研究方法提供理论依据。
