Kiyama H, Inagaki S, Kito S, Tohyama M
Brain Res. 1987 Feb;428(2):303-6. doi: 10.1016/0165-3806(87)90128-3.
The ontogeny of the neurotensin binding sites in the rat caudal cortex such as the retrosplenial cortex, the visual area containing area 17 and 18, the caudal somatosensory area and temporal area was examined by autoradiography. During the early postnatal period (from birth to day 10), very-high-density [3H]neurotensin binding sites were observed in the caudal cortical area, but the number of binding sites decreased markedly with age. On the other hand, the ventral tegmental area and substantia nigra pars compacta had a low density of binding sites at birth, but the density increased until about day 15 and remained even in the adult rat. These findings were confirmed by the biochemical binding analysis.
通过放射自显影术研究了大鼠尾侧皮质（如压后皮质、包含17区和18区的视觉区、尾侧体感区和颞区）中神经降压素结合位点的个体发生。在出生后早期（从出生到第10天），在尾侧皮质区域观察到非常高密度的[3H]神经降压素结合位点，但结合位点的数量随年龄显著减少。另一方面，腹侧被盖区和黑质致密部在出生时结合位点密度较低，但密度在约第15天前增加，并且在成年大鼠中仍保持。这些发现通过生化结合分析得到证实。
