Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Key Laboratory of Intelligent Optical Sensing and Manipulation, Ministry of Education, Department of Physics, Nanjing University, Nanjing 210093, China.
Wenzhou Key Laboratory of Biophysics, Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang 325000, China.
Nanoscale. 2024 Feb 15;16(7):3211-3225. doi: 10.1039/d3nr05557d.
Bacterial infections, especially antibiotic-resistant ones, remain a major threat to human health. Advances in nanotechnology have led to the development of numerous antimicrobial nanomaterials. Among them, peptide assemblies, formed by biomarker-triggered self-assembly of peptide-based building blocks, have received increasing attention due to their unique merits of good spatiotemporal controllability and excellent disease accumulation and retention. In recent years, a variety of "turn on" imaging probes and activatable antibacterial agents based on peptide assemblies have been developed, providing promising alternatives for the treatment and diagnosis of bacterial infections. In this review, we introduce representative design strategies for peptide assemblies and highlight the bacterial infection imaging and treatment applications of these supramolecular materials. Besides, current challenges in this field are proposed.
细菌感染，特别是抗生素耐药性细菌感染，仍然是对人类健康的主要威胁。纳米技术的进步导致了许多抗菌纳米材料的发展。在这些材料中，基于生物标志物触发的肽基构建块的自组装形成的肽组装体，由于其具有良好的时空可控性和优异的疾病积累和保留的独特优点，受到了越来越多的关注。近年来，已经开发出了多种基于肽组装体的“开启”成像探针和可激活的抗菌剂，为细菌感染的治疗和诊断提供了有前途的选择。在这篇综述中，我们介绍了肽组装体的代表性设计策略，并强调了这些超分子材料在细菌感染成像和治疗方面的应用。此外，还提出了该领域当前面临的挑战。
