Medical School, Southeast University, Nanjing 210009, China.
Hepatopancreatobiliary Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210009, China.
J Mater Chem B. 2022 Mar 2;10(9):1343-1358. doi: 10.1039/d1tb02646a.
Bacterial infection has received substantial attention and poses a serious threat to human health. Although antibiotics can effectively fight against bacterial infection, the occurrence of antibiotic resistance has become increasingly serious in recent years, which tremendously hinders its clinical application. Consequently, it is urgent to explore novel strategies to achieve efficacious treatment of bacterial diagnosis and detection. Manganese dioxide (MnO) nanomaterial has been extensively reported in tumor therapy. Nevertheless, there are few antibacterial reviews of MnO. Herein, we will discuss the applications of MnO in the detection and treatment of bacterial infection, including photodynamic therapy, immunotherapy, improvement of hypoxia, dual-modal combination therapy, reactive oxygen species scavenging, magnetic resonance imaging, optical application of acoustic imaging, and so forth. This review is expected to provide meaningful guidance on further research of MnO nanomaterial for antibacterial applications.
细菌感染受到了广泛关注，对人类健康构成了严重威胁。尽管抗生素可以有效对抗细菌感染，但近年来抗生素耐药性的发生变得越来越严重，极大地阻碍了其临床应用。因此，迫切需要探索新的策略来实现对细菌诊断和检测的有效治疗。二氧化锰（MnO）纳米材料在肿瘤治疗中得到了广泛的报道。然而，关于 MnO 的抗菌作用的研究却很少。本文将讨论 MnO 在细菌感染的检测和治疗中的应用，包括光动力治疗、免疫治疗、改善缺氧、双模态联合治疗、活性氧清除、磁共振成像、声成像的光学应用等。本文的综述有望为 MnO 纳米材料在抗菌应用方面的进一步研究提供有意义的指导。
