State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
ACS Nano. 2024 Feb 13;18(6):4957-4971. doi: 10.1021/acsnano.3c10623. Epub 2024 Jan 30.
Vaccine technology is effective in preventing and treating diseases, including cancers and viruses. The efficiency of vaccines can be improved by increasing the dosage and frequency of injections, but it would bring an extra burden to people. Therefore, it is necessary to develop vaccine-boosting techniques with negligible side effects. Herein, we reported a cupping-inspired noninvasive suction therapy that could enhance the efficacy of cancer/SARS-CoV-2 nanovaccines. Negative pressure caused mechanical immunogenic cell death and released endogenous adjuvants. This created a subcutaneous niche that would recruit and activate antigen-presenting cells. Based on this universal central mechanism, suction therapy was successfully applied in a variety of nanovaccine models, which include prophylactic/therapeutic tumor nanovaccine, photothermal therapy induced in situ tumor nanovaccine, and SARS-CoV-2 nanovaccine. As a well-established physical therapy method, suction therapy may usher in an era of noninvasive and high-safety auxiliary strategies when combined with vaccines.
疫苗技术在预防和治疗疾病方面非常有效，包括癌症和病毒。通过增加剂量和注射频率可以提高疫苗的效率，但这会给人们带来额外的负担。因此，有必要开发副作用极小的疫苗增强技术。在这里，我们报告了一种受拔罐启发的非侵入性负压抽吸疗法，可以增强癌症/SARS-CoV-2 纳米疫苗的疗效。负压引起机械免疫原性细胞死亡并释放内源性佐剂。这就创造了一个募集和激活抗原呈递细胞的皮下小生境。基于这一普遍的中心机制，抽吸疗法已成功应用于多种纳米疫苗模型，包括预防性/治疗性肿瘤纳米疫苗、光热治疗诱导的原位肿瘤纳米疫苗和 SARS-CoV-2 纳米疫苗。作为一种成熟的物理治疗方法，抽吸疗法与疫苗结合使用时，可能会开创一种非侵入性和高安全性辅助策略的时代。
