State Key Laboratory of Separation Membrane and Membrane Process, School of Chemistry, Tiangong University, Tianjin, 300387, China.
School of Chemical Engineering and Technology, Tiangong University, Tianjin, 300387, China.
Macromol Rapid Commun. 2024 May;45(9):e2300689. doi: 10.1002/marc.202300689. Epub 2024 Feb 8.
Polyionic liquid hydrogels attract increasing attention due to their unique properties and potential applications. However, research on amino acid-based polyionic liquid hydrogels is still in its infancy stage. Moreover, the effect of amino acid types on the properties of hydrogels is rarely studied to date. In this work, amino acid-based polyionic liquid hydrogels (D/L-PCAA hydrogels) are synthesized by copolymerizing vinyl choline-amino acid ionic liquids and acrylic acids using Al as a crosslinking agent and bacterial cellulose (BC) as a reinforcing agent. The effects of amino acid types on mechanical and antimicrobial properties are systematically investigated. D-arginine-based hydrogel (D-PCArg) shows the highest tensile strength (220.7 KPa), D-phenylalanine-based hydrogel (D-PCPhe) exhibits the highest elongation at break (1346%), and L-aspartic acid-based hydrogel (L-PCAsp) has the highest elastic modulus (206.9 KPa) and toughness (1.74 MJ m). D/L-PCAsp hydrogels demonstrate stronger antibacterial capacity against Escherichia coli and Staphylococcus aureus, and D/L-PCPhe hydrogels possess higher antifungal activity against Cryptococcus neoformans. Moreover, the resultant hydrogels exhibit prominent hemocompatibility and low toxicity, as well as excellent self-healing capabilities (86%) and conductivity (2.8 S m). These results indicate that D/L-PCAA hydrogel provides a promise for applications in wound dressings.
聚离子液体水凝胶因其独特的性能和潜在的应用而受到越来越多的关注。然而，基于氨基酸的聚离子液体水凝胶的研究仍处于起步阶段。此外，迄今为止，很少有研究报道氨基酸类型对水凝胶性能的影响。在这项工作中，通过将乙烯胆碱-氨基酸离子液体和丙烯酸共聚，以 Al 作为交联剂，细菌纤维素（BC）作为增强剂，合成了基于氨基酸的聚离子液体水凝胶（D/L-PCAA 水凝胶）。系统研究了氨基酸类型对机械性能和抗菌性能的影响。基于 D-精氨酸的水凝胶（D-PCArg）表现出最高的拉伸强度（220.7 KPa），基于 D-苯丙氨酸的水凝胶（D-PCPhe）表现出最高的断裂伸长率（1346%），基于 L-天冬氨酸的水凝胶（L-PCAsp）具有最高的弹性模量（206.9 KPa）和韧性（1.74 MJ m）。D/L-PCAsp 水凝胶对大肠杆菌和金黄色葡萄球菌表现出更强的抗菌能力，D/L-PCPhe 水凝胶对新型隐球菌表现出更高的抗真菌活性。此外，所得水凝胶表现出突出的血液相容性和低毒性，以及优异的自修复能力（86%）和导电性（2.8 S m）。这些结果表明，D/L-PCAA 水凝胶有望应用于伤口敷料。
