Simon J H, Tebbi C K, Freeman A I, Green D M, Brecher M L, Barcos M
Cancer. 1987 May 1;59(9):1566-70. doi: 10.1002/1097-0142(19870501)59:9<1566::aid-cncr2820590906>3.0.co;2-z.
The experience with the treatment of malignant histiocytosis has been disappointing. Despite modest treatment success with a combination of cyclophosphamide, Adriamycin (doxorubicin), vincristine and prednisone, the overall prognosis remains poor. There are only a few reports of prolonged complete remissions in pediatric patients. The following report describes two children who have had long-term remission with an aggressive combination chemotherapy program that included intrathecal prophylaxis. The chemotherapeutic regimen described merits further evaluation in a larger number of patients.
恶性组织细胞增多症的治疗经验令人失望。尽管环磷酰胺、阿霉素（多柔比星）、长春新碱和泼尼松联合治疗取得了一定成效，但总体预后仍然很差。仅有少数关于儿科患者长期完全缓解的报道。以下报告描述了两名儿童，他们通过包括鞘内预防的积极联合化疗方案实现了长期缓解。所描述的化疗方案值得在更多患者中进行进一步评估。
