外科部位感染患者的多重耐药性。
Multidrug Resistance among Patients with Surgical Site Infection in a Tertiary Care Centre.
机构信息
Department of Pharmacology, Universal College of Medical Sciences, Bhairahawa, Rupandehi, Nepal.
Department of Pharmacy, Universal College of Medical Sciences, Bhairahawa, Rupandehi, Nepal.
出版信息
JNMA J Nepal Med Assoc. 2023 Nov 1;61(267):882-885. doi: 10.31729/jnma.8353.
INTRODUCTION
Infections at surgical sites are a major problem all over the world. Pathogens linked to postoperative infections are becoming increasingly resistant to antibiotics, which presents a significant therapeutic challenge for surgeons and raises the financial burden placed on patients. The study aimed to find the prevalence of multidrug resistance among patients with surgical site infections in a tertiary care centre.
METHODS
A descriptive cross-sectional study was conducted from 3 November 2022 to 2 May 2023 among post-operative patients with surgical site infection after receiving ethical approval from the Institutional Review Committee. Swab samples were sent for antimicrobial susceptibility testing. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.
RESULTS
Among 147 patients with surgical site infection, the prevalence of multi-drug resistance was 95 (64.63%) (56.90-72.36, 95% Confidence Interval). Among them, 51 (53.68%) patients were in the 21-40 years age group and most of them were male 53 (55.79%).
CONCLUSIONS
The prevalence of multidrug-resistant cases was similar to other studies done in similar settings.
KEYWORDS
antimicrobial drug resistance; multidrug resistance; Staphylococcus aureus; surgical site infection.
介绍
手术部位感染是全世界的一个主要问题。与术后感染相关的病原体对抗生素的耐药性越来越强，这对外科医生来说是一个重大的治疗挑战，并增加了患者的经济负担。本研究旨在调查三级护理中心手术部位感染患者的多药耐药率。
方法
在获得机构审查委员会的伦理批准后，于 2022 年 11 月 3 日至 2023 年 5 月 2 日期间，对术后发生手术部位感染的患者进行了一项描述性横断面研究。采集拭子样本进行抗菌药物敏感性试验。采用便利抽样法。点估计值在 95%置信区间计算。
结果
在 147 例手术部位感染患者中，多药耐药率为 95 例（64.63%）（56.90-72.36，95%置信区间）。其中，51 例（53.68%）患者年龄在 21-40 岁之间，大多数为男性 53 例（55.79%）。
结论
多药耐药病例的流行率与其他在类似环境中进行的研究相似。
关键词
抗菌药物耐药性；多药耐药性；金黄色葡萄球菌；手术部位感染。
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