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老年服用血管紧张素受体阻滞剂患者的慢性锂中毒:病例报告。

Chronic Lithium Toxicity in Old Age Patients Taking Angiotensin Receptor Blocker: A Case Report.

机构信息

Norvic International Hospital, Thapathali, Kathmandu, Nepal.

Green City Hospital Pvt Ltd, Basundhara, Kathmandu, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2023 Nov 1;61(267):901-903. doi: 10.31729/jnma.8346.

Abstract

UNLABELLED

Chronic lithium toxicity is a potentially serious side effect on patients taking lithium for a prolonged period with the diagnosis of mood disorders. The toxicity is even higher in patients taking drugs that interfere with the metabolism of lithium like angiotensin receptor blockers and in older patients with reduced kidney function. In this report, we present the case of a 62-year-old woman who presented to the emergency department with symptoms including loose stools, generalised body weakness, slurred speech, coarse hand tremors, and dystonia persisting for fifteen days. She had been under lithium therapy for bipolar type 1 disorder for 15 years before experiencing these symptoms, which emerged shortly after the addition of telmisartan (angiotensinogen receptor blocker) for hypertension.

KEYWORDS

angiotensin receptor blocker; bipolar disorder; case reports; lithium; telmisartan.

摘要

中文译文

未注明

慢性锂中毒是一种潜在的严重副作用,发生在长期接受锂治疗的情绪障碍患者身上。在那些同时服用影响锂代谢的药物(如血管紧张素受体阻滞剂)和肾功能减退的老年患者中,毒性更高。在本报告中,我们介绍了一位 62 岁女性的病例,她因腹泻、全身无力、言语含糊、手部粗震颤和痉挛持续 15 天而到急诊科就诊。在出现这些症状之前,她因双相情感障碍 1 型已经接受锂治疗 15 年,这些症状出现在添加替米沙坦(血管紧张素受体阻滞剂)治疗高血压后不久。

关键词

血管紧张素受体阻滞剂;双相情感障碍;病例报告;锂;替米沙坦。

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本文引用的文献

1
Long-Term Lithium Therapy: Side Effects and Interactions.长期锂盐治疗:副作用与相互作用
Pharmaceuticals (Basel). 2023 Jan 3;16(1):74. doi: 10.3390/ph16010074.
3
Effect of age on the severity of chronic lithium poisoning.年龄对慢性锂中毒严重程度的影响。
Clin Toxicol (Phila). 2020 Nov;58(11):1023-1027. doi: 10.1080/15563650.2020.1726376. Epub 2020 Feb 18.
7
Lithium for maintenance treatment of mood disorders.锂盐用于心境障碍的维持治疗。
Cochrane Database Syst Rev. 2001;2001(2):CD003013. doi: 10.1002/14651858.CD003013.

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