Dr. Long is from the Health Corporation of America and Virginia College of Osteopathic Medicine, Blacksburg. Dr. Dunn is in private practice, Tampa, Florida. Drs. Hill and Akin are from the Department of Dermatology, Texas Tech University Health Sciences Center, Lubbock. Dr. Akin also is from Midland Dermatology and Skin Cancer Center, Texas. Dr. Goldberg is from DermSurgery Associates, Houston, Texas.
Cutis. 2023 Dec;112(6):E6-E11. doi: 10.12788/cutis.0915.
Toluidine blue (TB) is a metachromatic dye used as a stain in frozen sections in Mohs micrographic surgery (MMS). The current literature on the use of TB is sparse and generally qualitative in nature. The aim of this systematic review was to summarize and evaluate the existing literature analyzing TB use in MMS. The PubMed and Cochrane databases were searched for relevant studies published before December 1, 2019. Studies that analyzed the use of TB in frozen sections applicable to MMS were included. A total of 25 articles were reviewed, of which 12 fit the inclusion criteria. Our analysis showed that TB may play an important role in the successful diagnosis and treatment of particular cutaneous tumors.
甲苯胺蓝（TB）是一种用于冷冻切片的变色染料，在 Mohs 显微外科手术（MMS）中使用。目前关于 TB 使用的文献很少，且通常是定性的。本系统评价的目的是总结和评估现有的分析 TB 在 MMS 中应用的文献。检索了 2019 年 12 月 1 日前发表的相关研究，PubMed 和 Cochrane 数据库。纳入了分析适用于 MMS 的冷冻切片中 TB 使用的研究。共回顾了 25 篇文章，其中 12 篇符合纳入标准。我们的分析表明，TB 可能在成功诊断和治疗某些皮肤肿瘤方面发挥重要作用。
