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Targeted therapy done right: Direct sonic hedgehog inhibition for sonic hedgehog medulloblastoma.

作者信息

Nellan Anandani, Jackson Sadhana

机构信息

Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Neuro Oncol. 2024 Apr 5;26(4):623-624. doi: 10.1093/neuonc/noae018.

DOI:10.1093/neuonc/noae018
PMID:38290484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10995513/
Abstract
摘要

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Targeted therapy done right: Direct sonic hedgehog inhibition for sonic hedgehog medulloblastoma.正确实施的靶向治疗:针对音猬因子髓母细胞瘤的直接音猬因子抑制
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2
The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity.成神经管细胞瘤细胞起源的发育阶段限制了 Sonic hedgehog 通路的使用和药物敏感性。
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本文引用的文献

1
Intraventricular SHH inhibition proves efficient in SHH medulloblastoma mouse model and prevents systemic side effects.脑室中 SHH 抑制在 SHH 髓母细胞瘤小鼠模型中证明是有效的,并可预防全身副作用。
Neuro Oncol. 2024 Apr 5;26(4):609-622. doi: 10.1093/neuonc/noad191.
2
Recommendations for Cost-Conscious Treatment of Basal Cell Carcinoma.基底细胞癌的成本意识治疗建议。
Dermatol Ther (Heidelb). 2023 Sep;13(9):1959-1971. doi: 10.1007/s13555-023-00989-x. Epub 2023 Aug 2.
3
Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.SHH 亚型髓母细胞瘤中的巨噬细胞表现出与治疗方式相关的动态异质性。
Cell Rep. 2021 Mar 30;34(13):108917. doi: 10.1016/j.celrep.2021.108917.
4
Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.Hedgehog 通路抑制剂维莫德吉在 Tg.rasH2 小鼠和 Sprague-Dawley 大鼠中的致癌性评估。
Regul Toxicol Pharmacol. 2018 Feb;92:382-389. doi: 10.1016/j.yrtph.2017.12.015. Epub 2017 Dec 24.
5
Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor.接受靶向刺猬信号通路抑制剂治疗的髓母细胞瘤患儿出现不可逆的生长板融合。
Oncotarget. 2017 Sep 1;8(41):69295-69302. doi: 10.18632/oncotarget.20619. eCollection 2017 Sep 19.
6
Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.维莫德吉治疗晚期基底细胞癌患者的长期安全性和有效性:关键ERIVANCE BCC研究的最终更新
BMC Cancer. 2017 May 16;17(1):332. doi: 10.1186/s12885-017-3286-5.
7
Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.维莫德吉对复发性音猬因子亚组髓母细胞瘤具有靶向疗效:来自儿科脑肿瘤协作组II期研究PBTC-025B和PBTC-032的结果
J Clin Oncol. 2015 Aug 20;33(24):2646-54. doi: 10.1200/JCO.2014.60.1591. Epub 2015 Jul 13.
8
Management of pediatric and adult patients with medulloblastoma.小儿和成人髓母细胞瘤患者的管理。
Curr Treat Options Oncol. 2014 Dec;15(4):581-94. doi: 10.1007/s11864-014-0306-4.
9
Hedgehog pathway inhibitor HhAntag691 is a potent inhibitor of ABCG2/BCRP and ABCB1/Pgp.刺猬信号通路抑制剂HhAntag691是ABCG2/BCRP和ABCB1/Pgp的强效抑制剂。
Neoplasia. 2009 Jan;11(1):96-101. doi: 10.1593/neo.81264.