Targeted therapy done right: Direct sonic hedgehog inhibition for sonic hedgehog medulloblastoma.
作者信息
Nellan Anandani, Jackson Sadhana
机构信息
Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Surgical Neurology Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Neuro Oncol. 2024 Apr 5;26(4):623-624. doi: 10.1093/neuonc/noae018.
Abstract
摘要
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Intraventricular SHH inhibition proves efficient in SHH medulloblastoma mouse model and prevents systemic side effects.脑室中 SHH 抑制在 SHH 髓母细胞瘤小鼠模型中证明是有效的，并可预防全身副作用。
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Macrophages in SHH subgroup medulloblastoma display dynamic heterogeneity that varies with treatment modality.SHH 亚型髓母细胞瘤中的巨噬细胞表现出与治疗方式相关的动态异质性。
Cell Rep. 2021 Mar 30;34(13):108917. doi: 10.1016/j.celrep.2021.108917.
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Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague-Dawley rats.Hedgehog 通路抑制剂维莫德吉在 Tg.rasH2 小鼠和 Sprague-Dawley 大鼠中的致癌性评估。
Regul Toxicol Pharmacol. 2018 Feb;92:382-389. doi: 10.1016/j.yrtph.2017.12.015. Epub 2017 Dec 24.
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Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor.接受靶向刺猬信号通路抑制剂治疗的髓母细胞瘤患儿出现不可逆的生长板融合。
Oncotarget. 2017 Sep 1;8(41):69295-69302. doi: 10.18632/oncotarget.20619. eCollection 2017 Sep 19.
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Long-term safety and efficacy of vismodegib in patients with advanced basal cell carcinoma: final update of the pivotal ERIVANCE BCC study.维莫德吉治疗晚期基底细胞癌患者的长期安全性和有效性：关键ERIVANCE BCC研究的最终更新
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J Clin Oncol. 2015 Aug 20;33(24):2646-54. doi: 10.1200/JCO.2014.60.1591. Epub 2015 Jul 13.
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