Department of Dermatology, The University of Sydney at Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Melanoma Institute Australia, Wollstonecraft, New South Wales, Australia.
J Dermatol. 2024 Mar;51(3):353-364. doi: 10.1111/1346-8138.17126. Epub 2024 Jan 31.
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy that is associated with an increased risk of developing cutaneous malignancies. Clinical outcomes for these malignancies, including melanoma and keratinocyte cancers (KC), are worse for patients with CLL. Individuals with CLL develop an immunodeficiency of both the adaptive and innate immune system, which plays a role in the increased prevalence of skin cancers. This review focuses on the complex interplay between genetics, immunity, and pathogens that influence the cellular composition and biology of skin tumors and their microenvironment in CLL patients, and in comparison with other chronic hematological malignancies. It is paramount for dermatologists to be aware of the association between CLL (and chronic hematological malignancies more broadly) and cutaneous malignancies. This is a high-risk population who require regular and vigorous dermatologic follow-up.
慢性淋巴细胞白血病（CLL）是一种常见的淋巴恶性肿瘤，与皮肤恶性肿瘤的风险增加相关。这些恶性肿瘤的临床结局，包括黑色素瘤和角质形成细胞癌（KC），对 CLL 患者更差。CLL 患者的适应性和固有免疫系统均存在免疫缺陷，这在皮肤癌的高发中发挥了作用。本综述重点关注遗传、免疫和病原体之间的复杂相互作用，这些相互作用影响 CLL 患者皮肤肿瘤及其微环境的细胞组成和生物学特性，并与其他慢性血液恶性肿瘤进行了比较。皮肤科医生需要意识到 CLL（更广泛地说，还有慢性血液恶性肿瘤）与皮肤恶性肿瘤之间的关联。这是一个高危人群，需要定期进行积极的皮肤科随访。
