Kar Mitra, Sahu Chinmoy, Singh Pooja, Bhaisora Kamlesh Singh, Tejan Nidhi, Patel Sangram Singh, Ghoshal Ujjala
Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
J Glob Infect Dis. 2023 Nov 30;15(4):137-143. doi: 10.4103/jgid.jgid_66_23. eCollection 2023 Oct-Dec.
One of the rapidly escalating public health problems worldwide is traumatic brain injury (TBI) due to road traffic accidents. In comparison to postneurosurgery patients and other patients inhabiting the intensive care units (ICUs), patients with TBI are more susceptible to nosocomially acquired infections from the hospital milieu.
This retrospective study was conducted at a university hospital in Northern India from December 2018 to September 2022. All patients presenting with TBI formed the cohort of our study population.
A total of 72 patients with TBI were enrolled. The mean age of patients was 40.07 ± 18.31 years. The most common infections were ventilator-associated pneumonia (VAP) (44/72, 61.11%) and bloodstream infection (BSI) in 21 (21/72, 29.17%) patients. Concomitant infections were observed in 21 (21/72, 29.17%) patients. The common organism causing VAP was spp. (29/58, 50.0%), BSI was (10/23, 43.48%), urinary tract infection was (5/16, 31.25%), and surgical site infection was spp. (3/8, 37.5%) in TBI patients. An increased incidence of multidrug resistance was demonstrated in our patients. The increased length of hospital and ICU stay, ICU admission, intubation, diabetes mellitus, chronic kidney disease, and hypertension were statistically significant parameters that made TBI patients prone to develop an infection.
TBI patients suffering from underlying comorbidities are prone to develop infections with multidrug-resistant bacteria was observed among our study cohort which also mirrors the lack of adherence to infection control measures.
道路交通事故导致的创伤性脑损伤（TBI）是全球范围内迅速升级的公共卫生问题之一。与神经外科手术后患者及入住重症监护病房（ICU）的其他患者相比，TBI患者更容易受到医院环境中医院获得性感染的影响。
本回顾性研究于2018年12月至2022年9月在印度北部的一家大学医院进行。所有出现TBI的患者构成了我们的研究人群队列。
共纳入72例TBI患者。患者的平均年龄为40.07±18.31岁。最常见的感染是呼吸机相关性肺炎（VAP）（44/72，61.11%），21例（21/72，29.17%）患者发生血流感染（BSI）。21例（21/72，29.17%）患者观察到合并感染。TBI患者中，引起VAP的常见病原体是 菌属（29/58，50.0%），引起BSI的是 菌（10/23，43.48%），引起尿路感染的是 菌（5/16，31.25%），引起手术部位感染的是 菌属（3/8，37.5%）。我们的患者中多药耐药的发生率有所增加。住院和ICU住院时间延长、入住ICU、插管、糖尿病、慢性肾脏病和高血压是使TBI患者易于发生感染的具有统计学意义的参数。
在我们的研究队列中观察到，患有基础合并症的TBI患者容易发生耐多药细菌感染，这也反映出缺乏对感染控制措施的遵守情况。
