Kazemi Arya, Nourizadeh Amir Mohammad, Arjmand Ghazal, Haseli Sara, Askari Elham
Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Radiol Case Rep. 2024 Jan 13;19(4):1340-1343. doi: 10.1016/j.radcr.2023.12.060. eCollection 2024 Apr.
Lipofibroadenoma (LFA) is an epithelial tumor. It has been seen rarely in the thymus, and only a handful of cases have been reported. LFA is usually seen in the anterior mediastinum and is defined as a coalescence of epithelial thymic, adipose, and fibrotic tissue. We present a 30-year-old female who presented due to an unrelated traffic accident. An incidental mass was found in her left anterior superior mediastinum. After performing a complete excision, a histologic examination of the excised mass revealed it to be LFA of the thymus, which is extremely rare. The follow-up period was uneventful. LFA is a slow-growing benign tumor and is very similar to fibroadenoma of the breast. The etiology and clinical findings are yet to be well-defined. It was only seen in men in the prior cases. But recent cases, including this one, have also reported female patients. The tumor is mainly observed in the anterior mediastinum, which was also the case in our patient. The gold standard of diagnosis is pathologic examination. Our examination showed strands and nests of thymic parenchyma, including Hassall corpuscles, which separated fibro adipose tissue. Thymectomy is the treatment of choice. It can be performed by either video-assisted thoracic surgery or open surgery. We performed open surgery. The most important prognostic factor for this tumor is staging.
脂肪纤维腺瘤（LFA）是一种上皮性肿瘤。它在胸腺中很少见，仅有少数病例报道。LFA通常见于前纵隔，定义为上皮性胸腺组织、脂肪组织和纤维组织的融合。我们报告一例30岁女性，因一起无关的交通事故前来就诊。在其左前上纵隔偶然发现一个肿块。完整切除肿块后，对切除标本进行组织学检查，发现为胸腺脂肪纤维腺瘤，极为罕见。随访期间无异常情况。LFA是一种生长缓慢的良性肿瘤，与乳腺纤维腺瘤非常相似。其病因和临床特征尚未明确界定。既往病例仅见于男性，但包括本例在内的近期病例也有女性患者的报道。该肿瘤主要见于前纵隔，我们的患者也是如此。诊断的金标准是病理检查。我们的检查显示胸腺实质呈条索状和巢状，包括哈氏小体，其间分隔有纤维脂肪组织。胸腺切除术是首选治疗方法。可通过电视辅助胸腔镜手术或开放手术进行。我们实施的是开放手术。该肿瘤最重要的预后因素是分期。
