Singleton M A, Rosen J I, Fisher D M
Can J Anaesth. 1987 Mar;34(2):152-5. doi: 10.1007/BF03015333.
To evaluate whether there are age-related differences in the plasma concentration-vs-time course of fentanyl, the authors administered fentanyl to seven infants (3-10 months), seven children (1-9 years) and seven adults (18-41 years). Anaesthesia was induced with thiopentone, nitrous oxide, and pancuronium; following tracheal intubation, fentanyl (approximately 30 micrograms X kg-1 for infants and children, 20 micrograms X kg-1 for adults) was administered as a 2-min IV infusion. Anaesthesia was maintained with nitrous oxide, pancuronium, and morphine sulphate as clinically indicated. Plasma samples were obtained for 4 h and fentanyl concentrations determined by radioimmunoassay. Plasma concentrations per microgram X kg-1 fentanyl administered were lowest in infants 4-10 and 60-240 min after the start of the 2-min infusion; values for children were lower than those for adults 4, 180 and 210 min after the start of the 2-min infusion. These findings are consistent with the authors' clinical observation that infants tolerate larger doses of fentanyl than do adults.
为评估芬太尼血药浓度-时间过程是否存在年龄相关差异，作者对7名婴儿（3 - 10个月）、7名儿童（1 - 9岁）和7名成人（18 - 41岁）给予芬太尼。用硫喷妥钠、氧化亚氮和泮库溴铵诱导麻醉；气管插管后，以2分钟静脉输注方式给予芬太尼（婴儿和儿童约30微克/千克，成人20微克/千克）。根据临床指征，用氧化亚氮、泮库溴铵和硫酸吗啡维持麻醉。采集血样4小时，用放射免疫分析法测定芬太尼浓度。在2分钟输注开始后4 - 10分钟和60 - 240分钟，每微克/千克芬太尼给药后的血药浓度在婴儿中最低；在2分钟输注开始后4、180和210分钟，儿童的值低于成人。这些发现与作者的临床观察一致，即婴儿比成人能耐受更大剂量的芬太尼。
