Meretoja O A
Department of Anesthesiology, Children's Hospital, University of Helsinki, Finland.
Anesth Analg. 1989 Jan;68(1):20-4.
Eighty-one pediatric patients, ranging from neonates to adolescents, were studied during fentanyl-N2O-O2 anesthesia to determine for each of them the vecuronium infusion required to maintain 90-95% neuromuscular block (NMB). Electromyographic monitoring with train-of-four stimuli was used. The steady infusion rate was 62 +/- 15 (SD) micrograms.kg-1.hr-1 in neonates and infants. This rate was 40% of that required by children 3 to 10 years old (154 +/- 49 micrograms.kg-1.hr-1; P less than 0.05). In adolescents the vecuronium requirement was less than in children and was comparable to that reported in adults in other studies (89 +/- 13 micrograms.kg-1.hr-1). Despite considerable individual variation, the infusion rate could be reliably estimated on the basis of duration of greater than 90% NMB maintained by small doses of vecuronium given after intubation. Also, a close correlation existed between the duration of greater than 90% NMB maintained by 100 micrograms/kg of vecuronium and the individual infusion rate (r2 = 0.76).
对81例年龄从新生儿到青少年的儿科患者在芬太尼-氧化亚氮-氧气麻醉期间进行了研究，以确定维持90%至95%神经肌肉阻滞（NMB）所需的维库溴铵输注量。采用四个成串刺激的肌电图监测。新生儿和婴儿的稳定输注速率为62±15（标准差）微克·千克⁻¹·小时⁻¹。该速率为3至10岁儿童所需速率（154±49微克·千克⁻¹·小时⁻¹）的40%（P<0.05）。青少年的维库溴铵需求量低于儿童，与其他研究中报道的成人需求量相当（89±13微克·千克⁻¹·小时⁻¹）。尽管存在相当大的个体差异，但基于插管后给予小剂量维库溴铵维持大于90%NMB的持续时间，输注速率可以可靠地估计。此外，100微克/千克维库溴铵维持大于90%NMB的持续时间与个体输注速率之间存在密切相关性（r² = 0.76）。
