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埃塞俄比亚亚的斯亚贝巴新冠疫情野战医院新冠肺炎住院患者的静脉血栓栓塞症及相关因素

Venous Thromboembolism and Associated Factors in Hospitalized Patients with COVID-19 at Addis Ababa COVID-19 Field Hospital, Ethiopia.

作者信息

Haile Abel Teklit, Haile Robel Gemechu, Gebrehiwot Esrom Hagos, Abeje Eden Workalemahu

机构信息

Research Department, Saint Peter Specialized Hospital, Addis Ababa, Ethiopia.

Department of Internal Medicine, Wollo University, Dessie, Ethiopia.

出版信息

Infect Drug Resist. 2024 Jan 26;17:305-317. doi: 10.2147/IDR.S449401. eCollection 2024.

Abstract

BACKGROUND

The association of COVID-19 with venous thromboembolism is of particular interest as there are reports that have associated thrombotic events with the pandemic. COVID-19 may predispose to venous thromboembolism. There is initial evidence suggesting that individuals with COVID-19 may be more prone to developing venous thromboembolism (VTE). This study aims to assess venous thromboembolism and associated factors in 19 patients admitted to Addis Ababa's field hospital for COVID-19.

OBJECTIVE

To identify associated factors that affect the development of thromboembolism in patients admitted with the diagnosis of COVID-19.

METHODS

To determine the risks of VTE patients, an institution-based case control research was conducted using SPSS version 26, multivariable binary logistic regression analysis was used.

RESULTS

Significant factors associated with the development of VTE in COVID-19 patients included having a severe case (AOR = 0.38, 95% CI = 0.149-0.961), risk factors for VTE (AOR = 2.57, 95% CI = 1.18-5.33), diabetes (AOR = 3.745, 95% CI = 1.715-8.176), chest pain (AOR = 4.13, 95% CI = 1.89-9), stage 1 hypertension levels (AOR = 3.67, 95% CI = 1.37-9.836), and hospital anticoagulation (AOR = 11.78, 95% CI = 5.25-26.4).

CONCLUSION

The results of VTE in individuals with COVID-19 imply a direct association between severe COVID-19 and diabetes, having risk factors, hypertension, and hospital anticoagulation.

摘要

背景

新型冠状病毒肺炎(COVID-19)与静脉血栓栓塞的关联备受关注,因为有报道称血栓形成事件与该大流行病有关。COVID-19可能易引发静脉血栓栓塞。初步证据表明,COVID-19患者可能更易发生静脉血栓栓塞(VTE)。本研究旨在评估入住亚的斯亚贝巴野战医院的19例COVID-19患者的静脉血栓栓塞及相关因素。

目的

确定确诊为COVID-19的住院患者中影响血栓栓塞发生的相关因素。

方法

为确定VTE患者的风险,采用基于机构的病例对照研究,使用SPSS 26版进行多变量二元逻辑回归分析。

结果

与COVID-19患者发生VTE相关的显著因素包括重症(比值比[AOR]=0.38,95%置信区间[CI]=0.149 - 0.961)、VTE风险因素(AOR = 2.57,95% CI = 1.18 - 5.33)、糖尿病(AOR = 3.745,95% CI = 1.715 - 8.176)、胸痛(AOR = 4.13,95% CI = 1.89 - 9)、1级高血压水平(AOR = 3.67,95% CI = 1.37 - 9.836)以及医院抗凝治疗(AOR = 11.78,95% CI = 5.25 - 26.4)。

结论

COVID-19患者VTE的结果表明,重症COVID-19与糖尿病、存在风险因素、高血压及医院抗凝治疗之间存在直接关联。

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