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三嗪类化合物与脂多糖共同暴露对BalB/c小鼠睾丸和肝脏炎症反应及组织病理学变化的影响。

Influence of triazines and lipopolysaccharide coexposure on inflammatory response and histopathological changes in the testis and liver of BalB/c mice.

作者信息

Abarikwu Sunny O, Mgbudom-Okah Chidimma J, Ndufeiya-Kumasi Lauritta C, Monye Vivian E, Aruoren Oke, Ezim Ogechukwu E, Omeodu Stephen I, Charles Iniobong A

机构信息

Department of Biochemistry, University of Port Harcourt, Choba, Nigeria.

出版信息

Heliyon. 2024 Jan 12;10(2):e24431. doi: 10.1016/j.heliyon.2024.e24431. eCollection 2024 Jan 30.

DOI:10.1016/j.heliyon.2024.e24431
PMID:38293467
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10826326/
Abstract

BACKGROUND

Triazines are environmental active chemicals that have been reported to alter the inflammatory status of the gonads. We tested the anti-inflammatory effect of the triazines (atrazine; ATZ, simazine; SMZ and cyanazine; CYZ) on the testis and compared it with the more classical liver model that has substantial populations of resident macrophages comparable to the testis.

METHODS

BalB/c mice were treated with 25 mg/kg ATZ, SMZ and CYZ for 30 days and injected with lipopolysaccharide (0.5 mg/kg ) 6 h before sacrifice. Myeloperoxidase activity and nitric oxide level in the testis and liver homogenates were determined by spectrophotometry whereas tumor necrosis factor-alpha and interleukin-6 concentrations were evaluated by immunoassay. Haematoxylin and eosin stained sections of the tissues were observed using a light microscope.

RESULTS

Myeloperoxidase activity, nitric oxide, tumor necrosis factor-alpha, and interleukin-6 levels were decreased in the liver and testis of the triazines co-treated animals. SMZ has the most potent inhibitory effect and ATZ the least effect on inflammatory mediators in both tissues. Microscopic evaluation showed loss of inflammatory cells in the inter-tubular areas of the testis and few patchy masses of infiltrating inflammatory cells around the central vein of the liver.

CONCLUSION

Triazines inhibit the levels of inflammatory mediators in the testis and liver of mice. The anti-inflammatory effect of triazines in a lipopolysaccharide-induced inflammation model was established in this study.

摘要

背景

三嗪类是环境活性化学物质，据报道可改变性腺的炎症状态。我们测试了三嗪类（阿特拉津；ATZ、西玛津；SMZ和氰草津；CYZ）对睾丸的抗炎作用，并将其与更经典的肝脏模型进行比较，该模型中有大量与睾丸相当的常驻巨噬细胞。

方法

将BalB/c小鼠用25mg/kg的ATZ、SMZ和CYZ处理30天，并在处死前6小时注射脂多糖（0.5mg/kg）。通过分光光度法测定睾丸和肝脏匀浆中的髓过氧化物酶活性和一氧化氮水平，而通过免疫测定法评估肿瘤坏死因子-α和白细胞介素-6的浓度。使用光学显微镜观察组织的苏木精和伊红染色切片。

结果

在三嗪类联合处理的动物的肝脏和睾丸中，髓过氧化物酶活性、一氧化氮、肿瘤坏死因子-α和白细胞介素-6水平均降低。在两种组织中，SMZ对炎症介质的抑制作用最强，ATZ的作用最小。显微镜评估显示，睾丸曲管间区域的炎症细胞减少，肝脏中央静脉周围有少量散在的浸润性炎症细胞团块。

结论

三嗪类抑制小鼠睾丸和肝脏中炎症介质的水平。本研究建立了三嗪类在脂多糖诱导的炎症模型中的抗炎作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/cbd5f7a1ab10/gr14.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/44d0f2997ebd/gr3.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/d38bfdb29575/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/367cc0540178/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/4c6020bd390e/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/28c75eef81c9/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/3d318285377e/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/c4b932bf0ca3/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/2f4f494cda27/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0627/10826326/0f6471db0f98/gr12.jpg
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Characterization of Arsenic and Atrazine Contaminations in Drinking Water in Iowa: A Public Health Concern.爱荷华州饮用水中砷和阿特拉津污染的特征：公共健康问题。
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有棱南瓜籽可保护咖啡因处理大鼠的精子发生评分指数和睾丸组织学。
Andrologia. 2022 Dec;54(11):e14578. doi: 10.1111/and.14578. Epub 2022 Sep 3.
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