Alayyafi AbdulAziz A, Nasef Hany A, Salem Shereen E, Gomaa Esam A, AbouElleef Elsayed M
Chemistry Department, Al-Qunfudhah University College, Umm Al-Qura University, Saudi Arabia.
Basic Sciences Department, Delta Higher Institute for Engineering and Technology, 35681-Dakhlia, Mansoura, Egypt.
Heliyon. 2024 Jan 10;10(2):e24071. doi: 10.1016/j.heliyon.2024.e24071. eCollection 2024 Jan 30.
This study investigated the physicochemical properties of the interaction of indomethacin and copper chloride using the electrical conductance measurement in methanol, ethanol, and their binary mixture with water at room temperature (298.15 K), to determine the solvation behavior, redox behavior, and kinetics. The association parameters were computed using the Fuoss-Hsia-Fernández-Prini and Fuoss-Shedlovsky models. The standard Gibbs energy for association (ΔG), Walden product (Λη), and hydrodynamic radii (R) were calculated to study the interaction of indomethacin and copper chloride. On the other hand, cyclic voltammetry examines the electrochemical redox behavior of copper chloride using a gold electrode and its interactions with indomethacin. Results showed changes in peak potentials and currents density in the presence of indomethacin, indicating alterations in redox behavior and reaction rates. Overall, this research can be valuable in understanding the electrochemical properties and potential applications of indomethacin and copper chloride, as well as in developing new drugs or therapeutic agents, which could have has implications in various fields, including drug development, electrochemistry, and materials science.
本研究通过在室温（298.15 K）下于甲醇、乙醇及其与水的二元混合物中进行电导率测量，研究了吲哚美辛与氯化铜相互作用的物理化学性质，以确定溶剂化行为、氧化还原行为和动力学。使用福斯-夏-费尔南德斯-普里尼模型和福斯-谢德洛夫斯基模型计算缔合参数。计算了缔合的标准吉布斯自由能（ΔG）、瓦尔登乘积（Λη）和流体动力学半径（R），以研究吲哚美辛与氯化铜的相互作用。另一方面，循环伏安法使用金电极研究了氯化铜的电化学氧化还原行为及其与吲哚美辛的相互作用。结果表明，在存在吲哚美辛的情况下，峰电位和电流密度发生了变化，表明氧化还原行为和反应速率发生了改变。总体而言，这项研究对于理解吲哚美辛和氯化铜的电化学性质及潜在应用，以及开发新药或治疗剂可能具有重要价值，这可能在包括药物开发、电化学和材料科学在内的各个领域产生影响。
