Al-Thubaiti Eman Hillal
Biotechnology Department, College of Sciences, Taif University, Taif-P.O. Box 11099, Taif, 21944, Saudi Arabia.
Heliyon. 2023 Jun 21;9(6):e17468. doi: 10.1016/j.heliyon.2023.e17468. eCollection 2023 Jun.
Curcumin is an active component of the rhizome turmeric. Curcumin/zinc (Cur/Zn) complex was synthesized and characterized using the elemental analysis, the molar conductance, FT-IR, UV-Vis,HNMR, scanning (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The molar conductance value is very low, referring to the absence of Cl ions inside or outside chelate sphere confirming non electrolytic nature. Based on IR and electronic spectra curcumin C[bond, double bond]O group in enol form chelated to Zn (II) ion. The surface morphology of curcumin chelate with Zn showed elevated in particle size and irregular grains shaped with elongated morphology. Transmission electron microscopy revealed that the curcumin chelate with Zn has spherical black spots like shape with particle size range from (33-97 nm). The antioxidant activities of curcumin and Cur/Zn complex were assessed. Results showed that the Cur/Zn complex showed potent antioxidant activities than curcumin. For antibacterial activity, Curcumin/Zn showed inhibitory effect against both (+ve and -ve) gram bacteria ( and ) at very low concentration. Cur/Zn recorded antibacterial and inhibition activity at 0.009 against and at 0.625 against . Cur/Zn complex showed higher capacity in scavenging the ABTS radical, FARAP capacity and metal chelating activity than curcumin itself and it showed more scavenging and inhibition activity for DPPH. The synthesized complex of Cur/Zn showed potent antioxidant and antibacterial activities than curcumin itself and it may benefit in treatment of aging and degenerative diseases with elevated and excessive production of free radicals.
姜黄素是姜黄根茎的一种活性成分。合成了姜黄素/锌（Cur/Zn）络合物，并通过元素分析、摩尔电导率、傅里叶变换红外光谱（FT-IR）、紫外可见光谱（UV-Vis）、核磁共振氢谱（HNMR）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和X射线衍射（XRD）对其进行了表征。摩尔电导率值非常低，这表明螯合球内外不存在氯离子，证实了其非电解质性质。基于红外光谱和电子光谱，烯醇形式的姜黄素C=O基团与Zn（II）离子螯合。姜黄素与锌的螯合物的表面形态显示粒径增大，颗粒形状不规则，呈拉长形态。透射电子显微镜显示，姜黄素与锌的螯合物具有球形黑点状形状，粒径范围为（33-97纳米）。评估了姜黄素和Cur/Zn络合物的抗氧化活性。结果表明，Cur/Zn络合物比姜黄素表现出更强的抗氧化活性。对于抗菌活性，姜黄素/锌在非常低的浓度下对革兰氏阳性菌和革兰氏阴性菌均显示出抑制作用。Cur/Zn在0.009时对[具体细菌1]有抗菌和抑制活性，在0.625时对[具体细菌2]有抗菌和抑制活性。Cur/Zn络合物在清除ABTS自由基、铁还原抗氧化能力（FARAP）和金属螯合活性方面比姜黄素本身具有更高的能力，并且对DPPH表现出更强的清除和抑制活性。合成的Cur/Zn络合物比姜黄素本身表现出更强的抗氧化和抗菌活性，它可能有助于治疗自由基产生增加和过量的衰老及退行性疾病。
