College of Plant Protection, China Agricultural University, Beijing, China.
Key Laboratory of Seed Innovation, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Autophagy. 2024 May;20(5):1208-1209. doi: 10.1080/15548627.2024.2311542. Epub 2024 Feb 14.
Selective degradation of the endoplasmic reticulum (ER) by macroautophagy/autophagy (reticulophagy) is essential for maintaining ER morphology and homeostasis under environmental stresses. Several reticulophagy receptors have been identified in mammals and yeast, but their counterparts in plants have not been extensively explored yet. Recently, we demonstrated that the HVA22-family protein OsHLP1 is a reticulophagy receptor in rice plants, and its orthologs function similarly in plants. In this punctum, we discuss why the HVA22 family proteins are the reticulophagy receptors in plants and how reticulophagy is highly associated with plant immune response.
选择性降解内质网 (ER) 的巨自噬/自噬 (网噬) 对于维持 ER 形态和在环境胁迫下的内稳态是必不可少的。几种网噬受体已在哺乳动物和酵母中被鉴定出来，但在植物中尚未广泛探索其对应物。最近，我们证明了 HVA22 家族蛋白 OsHLP1 是水稻植物中网噬的受体，其同源物在拟南芥中也具有相似的功能。在这一点上，我们讨论了为什么 HVA22 家族蛋白是植物中网噬的受体，以及网噬与植物免疫反应的高度相关性。
