Department of Pharmaceutical Sciences, Faculty of Pharmacy, Superior University, Lahore, Punjab, 54000, Pakistan.
Department of Pharmacology, Jinnah Sindh Medical University, Karachi, 75510, Pakistan.
Nanomedicine (Lond). 2024 Feb;19(4):345-361. doi: 10.2217/nnm-2023-0251. Epub 2024 Jan 31.
Renal disorders pose a global health threat, with targeted drug-delivery systems emerging as a promising strategy to enhance therapy safety and efficacy. Recent efforts have harnessed targeted nanomaterials for kidney disease treatment. While some systems remain in the early stages, they show immense potential in delivering cargo to specific sites. Through animal model experimentations, it has been demonstrated to reduce systemic side effects and enhance treatment effectiveness. This review presents current strategies for kidney disorder treatment, emphasizing site-specific targeting critical to renal disease pathophysiology. Recent advancements in nano-drug delivery systems for kidney targeting are explored. Finally, toxicological aspects and prospects of the most promising kidney-targeting delivery systems are discussed in this review article.
肾脏疾病对全球健康构成威胁，靶向药物输送系统作为一种提高治疗安全性和疗效的有前途的策略而出现。最近的研究利用靶向纳米材料来治疗肾脏疾病。虽然一些系统仍处于早期阶段，但它们在将药物输送到特定部位方面显示出巨大的潜力。通过动物模型实验，已经证明可以减少全身副作用并提高治疗效果。本文综述了目前用于治疗肾脏疾病的策略，强调了针对肾脏疾病病理生理学的特定部位靶向的重要性。探讨了用于肾脏靶向的纳米药物输送系统的最新进展。最后，本文讨论了最有前途的肾脏靶向输送系统的毒理学方面和前景。
