Larsen Dennis, Erichsen Andreas, Masciotta Giorgia, Meier Sebastian, Beeren Sophie R
Department of Chemistry, Technical University of Denmark, Kemitorvet 207, DK-2800 Kongens Lyngby, Denmark.
Chem Commun (Camb). 2024 Feb 15;60(15):2090-2093. doi: 10.1039/d3cc05897b.
Large-ring cyclodextrins (CDs) are a comparatively unexplored family of macrocycles. We use high-resolution H-C HSQC NMR experiments to resolve the anomeric signals of at least 13 different size CDs in a mixture. Using a single titration experiment, we can quantify the individual binding capabilites of these structurally-related hosts, avoiding the need for cumbersome isolation.
大环环糊精（CDs）是一类相对未被充分探索的大环化合物。我们使用高分辨率的H-C HSQC NMR实验来解析混合物中至少13种不同大小环糊精的异头信号。通过单次滴定实验，我们可以量化这些结构相关主体的个体结合能力，而无需进行繁琐的分离。
