Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
The School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Scand J Gastroenterol. 2024 May;59(5):524-532. doi: 10.1080/00365521.2024.2310183. Epub 2024 Jan 31.
Oxyntic gland neoplasm (OGN) is a rare subtype of gastric cancer. The aim of this study is to evaluate the prevalence, clinicopathological features, effectiveness and safety of endoscopic treatment, as well as the prognosis of OGN.
We retrospectively analyzed the data of patients pathologically diagnosed with OGN at our hospital from November 1, 2019 to May 1, 2023.
A total of 36 patients with 45 lesions were identified, resulting in a disease frequency of 0.047% (36/76,832). The mean age was 55.0 ± 7.5 years, with a male-to-female ratio of about 1:1.12. Most lesions were ≤10 mm in size (84.4%), located in the upper third of the stomach (73.3%), exhibited slight elevation (75.5%), appeared whitish (55%), had dilated blood vessels on the surface (75.5%). 16 and 21 lesions were treated by precutting endoscopic mucosal resection (EMR-P) and endoscopic submucosal dissection (ESD), respectively. No significant differences were found between EMR-P and ESD in terms of en bloc resection rate (100% vs 100%, = 1.000), complete resection rate (100% vs 90.5%, = 0.495), and curative resection rate (93.8% vs 90.5%, = 1.000). No complications such as bleeding and perforation were observed. No recurrence or metastasis was observed during the follow-up period.
OGN is a rare tumor with unique clinical, endoscopic, and pathological characteristics. EMR-P and ESD are deemed safe and effective for treating OGNs. The relatively faster and easier EMR-P seems at least non-inferior to ESD, especially for removal of smaller OGNs. The overall prognosis is favorable.
胃泌酸腺肿瘤（OGN）是一种罕见的胃癌亚型。本研究旨在评估 OGN 的患病率、临床病理特征、内镜治疗的有效性和安全性，以及预后。
我们回顾性分析了 2019 年 11 月 1 日至 2023 年 5 月 1 日在我院经病理诊断为 OGN 的患者数据。
共发现 36 例 45 处病变，发病率为 0.047%（36/76832）。患者平均年龄为 55.0±7.5 岁，男女比例约为 1:1.12。大多数病变的大小≤10mm（84.4%），位于胃的上三分之一（73.3%），呈轻微隆起（75.5%），呈白色（55%），表面可见扩张的血管（75.5%）。16 处和 21 处病变分别行预切开内镜黏膜切除术（EMR-P）和内镜黏膜下剥离术（ESD）治疗。EMR-P 和 ESD 的整块切除率（100%比 100%，=1.000）、完全切除率（100%比 90.5%，=0.495）和治愈性切除率（93.8%比 90.5%，=1.000）均无显著差异。无出血、穿孔等并发症发生。随访期间无复发或转移。
OGN 是一种罕见肿瘤，具有独特的临床、内镜和病理特征。EMR-P 和 ESD 是治疗 OGN 的安全有效的方法。相对更快、更简单的 EMR-P 似乎至少不逊于 ESD，尤其是对于较小的 OGN 的切除。总体预后良好。
