Astellas Pharma Global Development, Inc., Northbrook, IL, USA.
Astellas US LLC, Northbrook, IL, USA.
Expert Rev Pharmacoecon Outcomes Res. 2024 Apr;24(4):521-532. doi: 10.1080/14737167.2024.2311305. Epub 2024 Feb 26.
We describe the impact of acute myeloid leukemia (AML) diagnosis on workplace absenteeism and disability days among patients and their caregivers.
This retrospective study included adults with newly diagnosed AML (2009-2019) and adult caregivers of patients with newly diagnosed AML, identified from the US Merative™ MarketScan® Commercial Database. The Merative MarketScan Health and Productivity Management Database provided linked patient-level records of workplace absence and short-term (STD) and long-term disability (LTD) data. Endpoints included workplace absence, STD and LTD for patients and caregivers during 12 months pre-AML (baseline) and ≤3 years' follow-up, and corresponding cost of work loss.
Patient workplace absence decreased in the months post-AML diagnosis, but the number of STD and LTD leave days claimed increased significantly by sixfold and fourfold, respectively. The proportion of patients making STD leave claims increased within 4-5 months of diagnosis, while the proportion making LTD leave claims increased significantly starting from month 5. Caregiver workplace absence peaked in the first 2 months post-diagnosis and remained elevated versus baseline throughout the study.
AML diagnosis leads to workplace absenteeism and increased economic burden for patients with AML and their caregivers.
我们描述了急性髓系白血病（AML）诊断对患者及其护理人员的工作场所缺勤和残疾天数的影响。
这项回顾性研究纳入了 2009 年至 2019 年期间新诊断为 AML 的成年人，以及新诊断为 AML 的患者的成年护理人员，他们来自美国 Merative MarketScan 商业数据库。Merative MarketScan 健康与生产力管理数据库提供了与工作场所缺勤以及短期（STD）和长期残疾（LTD）数据相关联的患者级记录。终点包括在 AML 前 12 个月（基线）和随访时间≤3 年内患者和护理人员的工作场所缺勤、STD 和 LTD，以及相应的工作损失成本。
AML 诊断后患者的工作场所缺勤人数减少，但 STD 和 LTD 休假天数分别显著增加了六倍和四倍。诊断后 4-5 个月内，申请 STD 休假的患者比例增加，而申请 LTD 休假的比例从第 5 个月开始显著增加。护理人员的工作场所缺勤率在诊断后前 2 个月达到峰值，并在整个研究期间持续高于基线。
AML 诊断导致 AML 患者及其护理人员工作场所缺勤和经济负担增加。
