Xiaoxuan Li, Shuo Zhang, Shanshan Li, Mengxia Yu, Tianying Yao, Yuxin Shen, Jiang Li, Mingxia Chen
The First College of Clinical Medical Science, China Three Gorges University, Yichang, China.
School of Nursing, Nanjing Medical University, Nanjing, China.
Cancer Med. 2025 May;14(9):e70875. doi: 10.1002/cam4.70875.
Pancreatic cancer patients face varying medical expenses at different stages of treatment, resulting in dynamic changes in their financial toxicity. Longitudinal data collection is necessary to characterize the trajectory of these financial toxicity changes.
To Explore Potential Trajectories and Influencing Factors of Financial Toxicity among Pancreatic Cancer Patients.
This was a prospective observational research study performed according to STROBE Checklist.
From August 2022 to August 2023, we conducted inpatient data collection from pancreatic cancer patients in three hospitals in Jiangsu Province.
The COST scale was employed to investigate financial toxicity at four time points: upon admission (T0), at discharge (T1), 3 months post-discharge (T2), and 6 months post-discharge (T3). A latent growth model was utilized to classify the trajectories of financial toxicity and explore its influencing factors.
The identification of financial toxicity trajectories among pancreatic cancer patients revealed three potential categories: a high-risk-financial toxicity stable group (19.69%), a moderate-risk-financial toxicity stable group (56.37%), and a low-risk-financial toxicity stable group (23.94%). Logistic regression analysis showed that, compared to the low-risk-financial toxicity stable group, the primary influencing factors for the high-risk-financial toxicity stable group were self-efficacy and total out-of-pocket medical expenses. In contrast to the low-risk-financial toxicity stable group, the moderate-risk-financial toxicity stable group was influenced by self-efficacy and total monthly household income. When comparing the moderate-risk-financial toxicity stable group to the high-risk-financial toxicity stable group, factors such as ACCI, employment status, total out-of-pocket medical expenses, and distance to healthcare facilities emerged as significant.
The financial toxicity among pancreatic cancer patients has been categorized into three distinct trajectory patterns, each exhibiting significant population heterogeneity. It is imperative that we acknowledge the profound impact of financial toxicity on pancreatic cancer patients and strengthen relevant preventive and control measures to enhance their quality of life and therapeutic outcomes.
胰腺癌患者在治疗的不同阶段面临不同的医疗费用，导致其经济毒性发生动态变化。需要收集纵向数据来描述这些经济毒性变化的轨迹。
探索胰腺癌患者经济毒性的潜在轨迹及其影响因素。
这是一项根据STROBE清单进行的前瞻性观察性研究。
2022年8月至2023年8月，我们收集了江苏省三家医院胰腺癌患者的住院数据。
使用COST量表在四个时间点调查经济毒性：入院时（T0）、出院时（T1）、出院后3个月（T2）和出院后6个月（T3）。采用潜在增长模型对经济毒性轨迹进行分类并探索其影响因素。
胰腺癌患者经济毒性轨迹的识别显示出三种潜在类别：高风险经济毒性稳定组（19.69%）、中度风险经济毒性稳定组（56.37%）和低风险经济毒性稳定组（23.94%）。逻辑回归分析表明，与低风险经济毒性稳定组相比，高风险经济毒性稳定组的主要影响因素是自我效能感和自付医疗费用总额。与低风险经济毒性稳定组相比，中度风险经济毒性稳定组受自我效能感和家庭月总收入的影响。将中度风险经济毒性稳定组与高风险经济毒性稳定组进行比较时，ACCI、就业状况、自付医疗费用总额和到医疗机构的距离等因素具有显著意义。
胰腺癌患者的经济毒性已被分为三种不同的轨迹模式，每种模式都表现出显著的人群异质性。我们必须认识到经济毒性对胰腺癌患者的深远影响，并加强相关的预防和控制措施，以提高他们的生活质量和治疗效果。
