Tarter R E, Sclabassi R J, Sandford S L, Hays A L, Carra J P, Van Thiel D H
Clin Electroencephalogr. 1987 Jan;18(1):15-9.
Visual, auditory and somatosensory event related potentials were recorded from 58 patients with chronic nonalcoholic liver disease. The results of this study indicate that a significant, although somewhat modest, amount of variance on brainstem auditory, pattern visual and somatosensory ERP latency can be predicted by routinely obtained liver functional measures, albumin, prothrombin time, fasting ammonia level, globulin and especially indocyanine green clearance. Moreover, these associations are present in persons who are not overtly encephalopathic, underscoring the sensitivity of neurophysiologic measurement for detecting hepatic encephalopathy concomitant to only moderate severity of hepatic injury.
对58例慢性非酒精性肝病患者记录了视觉、听觉和体感事件相关电位。本研究结果表明，通过常规获得的肝功能指标，如白蛋白、凝血酶原时间、空腹血氨水平、球蛋白，尤其是吲哚菁绿清除率，可以预测脑干听觉、图形视觉和体感ERP潜伏期的显著差异，尽管这种差异程度相对较小。此外，这些关联存在于无明显肝性脑病的患者中，这突出了神经生理学测量对于检测仅伴有中度肝损伤的肝性脑病的敏感性。
