Kawarabayashi T, Yasunari K, Kanayama Y, Takeuchi K, Takeda T
Clin Exp Pharmacol Physiol. 1986 Nov-Dec;13(11-12):783-90. doi: 10.1111/j.1440-1681.1986.tb02382.x.
Intra-erythrocyte water, sodium and potassium contents were measured in spontaneously hypertensive rats (SHR) and deoxycorticosterone acetate (DOCA)-salt rats. In 12 week old SHR, the intra-erythrocyte water content was slightly but significantly lower than that in age-matched Wistar-Kyoto (WKY) rats. SHR also exhibited a significantly lower intra-erythrocyte potassium content, but sodium content tended to be elevated. Although sodium content was not correlated with the water content, potassium content was. In DOCA-salt hypertensive rats, the intra-erythrocyte sodium content was higher than that in age-matched normotensive Sprague-Dawley rats by about 33%, but the water and potassium contents were similar. There were no significant correlations between these parameters. These findings provide no evidence of water retention in erythrocytes from DOCA-salt rat or SHR even though intra-erythrocyte sodium content was increased.
测定了自发性高血压大鼠（SHR）和醋酸脱氧皮质酮（DOCA）-盐性大鼠红细胞内的水、钠和钾含量。在12周龄的SHR中，红细胞内水含量略低于但显著低于年龄匹配的Wistar-Kyoto（WKY）大鼠。SHR的红细胞内钾含量也显著降低，但钠含量有升高趋势。虽然钠含量与水含量不相关，但钾含量与水含量相关。在DOCA-盐性高血压大鼠中，红细胞内钠含量比年龄匹配的正常血压Sprague-Dawley大鼠高约33%，但水和钾含量相似。这些参数之间无显著相关性。这些发现表明，即使红细胞内钠含量增加，DOCA-盐性大鼠或SHR的红细胞中也没有水潴留的证据。
