Furspan P B, Bohr D F
Hypertension. 1985 Nov-Dec;7(6 Pt 1):860-6. doi: 10.1161/01.hyp.7.6.860.
Lymphocyte number and weight and their sodium and potassium contents and net passive fluxes were measured in spontaneously hypertensive stroke-prone rats, deoxycorticosterone acetate-treated rats, and two-kidney, one clip renal hypertensive rats. Wistar-Kyoto rats were used as controls for the spontaneously hypertensive stroke-prone rats, and normal intact Sprague-Dawley rats were used as controls for the others. Blood lymphocyte count was higher and lymphocyte weight was lower in the hypertensive rats. Intralymphocytic sodium content (millimoles per kilogram of dry weight) was elevated in the three forms of hypertension as compared with control values (spontaneously hypertensive stroke-prone rats, 43.0 +/- 1.7 vs Wistar-Kyoto rats, 37.3 +/- 1.3; deoxycorticosterone acetate-treated rats, 44.4 +/- 3.1 vs Sprague-Dawley rats, 36.1 +/- 1.7; one-kidney, one clip rats, 50.5 +/- 3.7 vs Sprague-Dawley rats, 38.9 +/- 2.0). Intralymphocytic potassium content was not significantly altered in any of the forms of hypertension. Lymphocytes from spontaneously hypertensive stroke-prone rats and deoxycorticosterone acetate-treated rats exhibited elevated net sodium fluxes (millimoles per kilogram of dry weight per hour) as compared with those of controls (spontaneously hypertensive stroke-prone rats, 7.00 +/- 0.99 vs Wistar-Kyoto rats, 4.89 +/- 0.63; deoxycorticosterone acetate-treated rats, 7.58 +/- 0.97 vs Sprague-Dawley rats, 5.6 +/- 0.64). Net potassium fluxes were significantly elevated only in the spontaneously hypertensive stroke-prone rats (14.07 +/- 1.70 vs 8.23 +/- 1.04 in Wistar-Kyoto rats). Sodium and potassium fluxes in lymphocytes from two-kidney, one clip rats and Sprague-Dawley rats were not significantly different.(ABSTRACT TRUNCATED AT 250 WORDS)
对自发性高血压易中风大鼠、醋酸脱氧皮质酮处理的大鼠以及两肾一夹肾性高血压大鼠的淋巴细胞数量、重量及其钠、钾含量和净被动通量进行了测量。将Wistar-Kyoto大鼠用作自发性高血压易中风大鼠的对照，将正常完整的Sprague-Dawley大鼠用作其他大鼠的对照。高血压大鼠的外周血淋巴细胞计数较高，淋巴细胞重量较低。与对照值相比，三种高血压模型中淋巴细胞内钠含量（每千克干重毫摩尔数）均升高（自发性高血压易中风大鼠，43.0±1.7 vs Wistar-Kyoto大鼠，37.3±1.3；醋酸脱氧皮质酮处理的大鼠，44.4±3.1 vs Sprague-Dawley大鼠，36.1±1.7；一肾一夹大鼠，50.5±3.7 vs Sprague-Dawley大鼠，38.9±2.0）。在任何一种高血压模型中，淋巴细胞内钾含量均无显著变化。与对照组相比，自发性高血压易中风大鼠和醋酸脱氧皮质酮处理的大鼠的淋巴细胞净钠通量（每千克干重每小时毫摩尔数）升高（自发性高血压易中风大鼠，7.00±0.99 vs Wistar-Kyoto大鼠，4.89±0.63；醋酸脱氧皮质酮处理的大鼠，7.58±0.97 vs Sprague-Dawley大鼠，5.6±0.64）。仅自发性高血压易中风大鼠的净钾通量显著升高（14.07±1.70 vs Wistar-Kyoto大鼠的8.23±1.04）。两肾一夹大鼠和Sprague-Dawley大鼠淋巴细胞中的钠和钾通量无显著差异。（摘要截断于250字）
