Graduate School of Organic Materials Science, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
Faculty of Engineering, Department of Polymeric and Organic Materials Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa, Yamagata, 992-8510, Japan.
Anal Bioanal Chem. 2024 Mar;416(7):1635-1645. doi: 10.1007/s00216-024-05165-4. Epub 2024 Jan 31.
This study demonstrated for the first time that skin surface pH can be monitored in real-time, using a screen-printed wearable pH sensor, to evaluate the buffering capacity of the human skin. The screen-printed pH sensor was composed of a polyaniline-based pH-sensitive electrode and a nitrocellulose membrane-based liquid junction type of Ag/AgCl reference electrode. This sensor showed a reliable and reversible potentiometric response to pH with long-term potential stability. Intermittent monitoring of the buffering capacity of skin surface pH demonstrated the reliability of the proposed wearable pH sensor, which was comparable to that of a commercially available flat-tip pH sensor. We found that contact of the wearable pH sensor with the subject's skin via aqueous electrolyte solutions was necessary for the sensor to continuously monitor the skin surface pH while sustaining the natural buffer capacity of the human skin surface.
本研究首次证明，可使用印刷式可穿戴 pH 传感器实时监测皮肤表面 pH 值，以评估人体皮肤的缓冲能力。印刷式 pH 传感器由基于聚苯胺的 pH 敏感电极和基于硝酸纤维素膜的液接型 Ag/AgCl 参比电极组成。该传感器对 pH 值表现出可靠且可逆的电位响应，具有长期的稳定性。间歇性监测皮肤表面 pH 值的缓冲能力证明了所提出的可穿戴 pH 传感器的可靠性，与市售的平头 pH 传感器相当。我们发现，可穿戴 pH 传感器与受试者皮肤接触，通过水基电解质溶液，传感器才能在维持人体皮肤表面自然缓冲能力的同时，持续监测皮肤表面 pH 值。
