Guangzhou Key Laboratory of Sensing Materials & Devices, Center for Advanced Analytical Science, School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou 510006, P. R. China.
School of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun 558000, China.
Anal Chem. 2022 May 24;94(20):7319-7328. doi: 10.1021/acs.analchem.2c00684. Epub 2022 May 10.
Sweat pH is a critical indicator for evaluating human health. With the extensive attention on the wearable and flexible biosensing devices, the technology for the monitoring of human sweat can be realized. In this study, a sensitive, miniaturized, and flexible electrochemical sweat pH sensor was developed for the continuous and real-time monitoring of the hydrogen-ion concentration in human sweat. A flexible electrode was fabricated on the poly(ethylene terephthalate) (PET) substrate by a simple and low-cost screen-printing technology, which was based on the integration of fluoroalkyl silane-functionalized TiCT (F-TiCT) and the polyaniline (PANI) membrane technology instead of the traditional ion-sensitive membrane. The surface functionalization strategy for TiCT with perfluorodecyltrichlorosilane can provide environmental stability. Functionalized TiCT (F-TiCT) was doped with PANI to obtain improved responsiveness, sensitivity, and reversibility. The constructed microsize, portable, and wearable F-TiCT/PANI pH sensor aimed to real-time monitor the pH value of human sweat during exercise. On-body sweat pH monitoring for females and males, respectively, exhibited high accuracy and continuous stability compared with ex situ analyses. This study thus offers a facile and practical solution for developing a highly reliable MXene-based mini-type pH sensor to realize the online monitoring of human sweat pH.
汗液 pH 值是评估人体健康的关键指标。随着对可穿戴和灵活生物传感设备的广泛关注，人体汗液监测技术得以实现。在这项研究中，开发了一种灵敏、微型化、灵活的电化学汗液 pH 值传感器，用于连续和实时监测人体汗液中的氢离子浓度。通过简单且低成本的丝网印刷技术在聚对苯二甲酸乙二醇酯 (PET) 基底上制造了柔性电极，该技术基于氟烷基硅烷功能化 TiCT（F-TiCT）和聚苯胺（PANI）膜技术的集成，而不是传统的离子敏感膜。全氟癸基三氯硅烷对 TiCT 的表面功能化策略可提供环境稳定性。用 PANI 掺杂功能化 TiCT（F-TiCT）可提高响应性、灵敏度和可逆性。构建的微尺寸、便携式和可穿戴 F-TiCT/PANI pH 传感器旨在实时监测运动过程中人体汗液的 pH 值。与原位分析相比，对女性和男性的体汗 pH 值监测分别表现出了较高的准确性和连续稳定性。因此，该研究为开发基于 MXene 的高可靠性微型 pH 传感器以实现人体汗液 pH 值的在线监测提供了一种简便实用的解决方案。
