Kubo Mahiro, Abe Mayuko, Le Bourdonnec Etienne, Wu Sheau-Chyi, Hsu To-En, Inoue Takao, Guo Yuanyuan
Department of Materials Science and Engineering, School of Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan.
Department of Earth Science, School of Science, Tohoku University, Sendai, Miyagi 980-8579, Japan.
ACS Meas Sci Au. 2025 Mar 6;5(2):208-215. doi: 10.1021/acsmeasuresciau.4c00092. eCollection 2025 Apr 16.
Temperature plays a crucial role in biological functions in normal physiological and pathological states and is intricately linked with chemical dynamics at the cellular, circuit, and system levels. Despite advances in temperature measurement technologies for internal monitoring, systems capable of simultaneously tracking localized temperature and chemical changes are still underdeveloped. In this study, we introduce dual-sensing hybrid fibers with a miniature footprint of <400 μm in diameter, fabricated using the thermal drawing process. These fibers exhibit precise temperature sensitivity, detecting changes as small as 0.5 °C, and demonstrate highly sensitive and reversible pH detection, a critical physiological parameter. Furthermore, through laser micromachining and surface functionalization, we highlight the potential of these fibers for wearable applications in dual pH and temperature sensing. This innovative dual-sensing technology offers a versatile platform for probing temperature and chemical signaling and wearable applications, with significant implications for therapeutic development and a deeper understanding of biological processes in various environments.
温度在正常生理和病理状态下的生物功能中起着至关重要的作用，并且在细胞、回路和系统层面与化学动力学有着复杂的联系。尽管用于内部监测的温度测量技术取得了进展，但能够同时跟踪局部温度和化学变化的系统仍未得到充分发展。在本研究中，我们介绍了采用热拉伸工艺制造的直径小于400μm的微型双传感混合纤维。这些纤维表现出精确的温度敏感性，能够检测低至0.5°C的变化，并展示出对关键生理参数pH的高度敏感且可逆的检测。此外，通过激光微加工和表面功能化，我们突出了这些纤维在双pH和温度传感可穿戴应用中的潜力。这种创新的双传感技术为探测温度和化学信号以及可穿戴应用提供了一个多功能平台，对治疗学发展以及深入理解各种环境中的生物过程具有重要意义。
