类风湿关节炎患者的中风风险：探索关联及其对患者护理的意义。
Stroke risk in rheumatoid arthritis patients: exploring connections and implications for patient care.
机构信息
Department of Internal Medicine, Ascension Saint Francis Hospital, Evanston, IL, 60202, USA.
Department of Psychology and Neuroscience, Duke University, Durham, NC, 27708, USA.
出版信息
Clin Exp Med. 2024 Jan 31;24(1):30. doi: 10.1007/s10238-023-01288-7.
Abstract
Rheumatoid arthritis (RA) can independently increase the risk of stroke, affecting both young and adult RA patients. Recent attention has been drawn to the association between stroke and RA, supported by mounting evidence. Given that stroke is a significant and an urgent public health concern, this review aims to highlight the relationship between stroke and RA, covering mechanisms, underlying risk factors, early detection tools, and treatment implications. By uncovering the connection that links RA to stroke, we can pave the way for targeted healthcare practices and the development of preventive strategies for individuals with RA. Therefore, further research is imperative to deepen our understanding of this association and, ideally, guide treatment decisions for individuals at risk of both RA and stroke.
摘要
类风湿性关节炎 (RA) 可独立增加中风风险，影响年轻和成年 RA 患者。越来越多的证据支持 RA 与中风之间存在关联，这引起了最近的关注。鉴于中风是一个重大且紧迫的公共卫生问题，本综述旨在强调中风和 RA 之间的关系，涵盖发病机制、潜在风险因素、早期检测工具和治疗意义。通过揭示 RA 与中风之间的联系，我们可以为 RA 患者制定有针对性的医疗实践和预防策略铺平道路。因此，进一步的研究对于加深我们对这种关联的理解并为同时患有 RA 和中风风险的个体提供治疗决策指导至关重要。
相似文献
1
Stroke risk in rheumatoid arthritis patients: exploring connections and implications for patient care.类风湿关节炎患者的中风风险：探索关联及其对患者护理的意义。
Clin Exp Med. 2024 Jan 31;24(1):30. doi: 10.1007/s10238-023-01288-7.
2
Rheumatoid Arthritis, Anti-Cyclic Citrullinated Peptide Positivity, and Cardiovascular Disease Risk in the Women's Health Initiative.类风湿关节炎、抗环瓜氨酸肽抗体阳性与妇女健康倡议中的心血管疾病风险。
Arthritis Rheumatol. 2015 Sep;67(9):2311-22. doi: 10.1002/art.39198.
3
Derivation and internal validation of a multi-biomarker-based cardiovascular disease risk prediction score for rheumatoid arthritis patients.基于多种生物标志物的类风湿关节炎患者心血管疾病风险预测评分的推导和内部验证。
Arthritis Res Ther. 2020 Dec 4;22(1):282. doi: 10.1186/s13075-020-02355-0.
4
5
Presence of autoantibodies in "seronegative" rheumatoid arthritis associates with classical risk factors and high disease activity.“血清阴性”类风湿关节炎中自身抗体的存在与经典危险因素及高疾病活动度相关。
Arthritis Res Ther. 2020 Jul 16;22(1):170. doi: 10.1186/s13075-020-02191-2.
6
Anti-CCP2 is an adjunct to, not a surrogate for, rheumatoid factor in the diagnosis of rheumatoid arthritis: diagnostic utility of anti-CCP2 antibodies in Egyptian patients with rheumatoid arthritis.抗环瓜氨酸肽2（Anti-CCP2）在类风湿关节炎诊断中是类风湿因子的辅助指标而非替代指标：抗CCP2抗体在埃及类风湿关节炎患者中的诊断效用
Scand J Rheumatol. 2008 Sep-Oct;37(5):329-36. doi: 10.1080/03009740802116208.
7
Complex Relationships of Smoking, HLA-DRB1 Genes, and Serologic Profiles in Patients With Early Rheumatoid Arthritis: Update From a Swedish Population-Based Case-Control Study.早期类风湿关节炎患者吸烟、HLA-DRB1 基因与血清学特征的复杂关系：来自瑞典基于人群的病例对照研究的更新。
Arthritis Rheumatol. 2019 Sep;71(9):1504-1511. doi: 10.1002/art.40852. Epub 2019 Jul 24.
8
Anti-Citrullinated Protein Antibody Specificities, Rheumatoid Factor Isotypes, and Incident Cardiovascular Events in Patients With Rheumatoid Arthritis.抗瓜氨酸化蛋白抗体特异性、类风湿因子同种型与类风湿关节炎患者心血管事件的发生。
Arthritis Rheumatol. 2020 Oct;72(10):1658-1667. doi: 10.1002/art.41381. Epub 2020 Sep 7.
9
Occurrence of anti-CCP2 and RF isotypes and their relation to age and disease severity among Sudanese patients with rheumatoid arthritis.在苏丹类风湿关节炎患者中，抗 CCP2 和 RF 同种型的出现及其与年龄和疾病严重程度的关系。
Clin Rheumatol. 2019 Jun;38(6):1545-1553. doi: 10.1007/s10067-019-04431-6. Epub 2019 Jan 17.
10
Autoantibodies to cyclic citrullinated peptide 2 (CCP2) are superior to other potential diagnostic biomarkers for predicting rheumatoid arthritis in early undifferentiated arthritis.抗环瓜氨酸肽2（CCP2）自身抗体在预测早期未分化关节炎中的类风湿关节炎方面优于其他潜在的诊断生物标志物。
Clin Rheumatol. 2007 Oct;26(10):1627-33. doi: 10.1007/s10067-007-0558-5. Epub 2007 Feb 8.
引用本文的文献
1
Subclinical myocardial changes in rheumatoid arthritis: cardiovascular magnetic resonance evidence of immuno-inflammatory remodeling.类风湿关节炎的亚临床心肌改变：免疫炎症重塑的心血管磁共振证据
Front Cardiovasc Med. 2025 Aug 21;12:1607018. doi: 10.3389/fcvm.2025.1607018. eCollection 2025.
2
Deciphering Mechanisms, Prevention Strategies, Management Plans, Medications, and Research Techniques for Strokes in Systemic Lupus Erythematosus.系统性红斑狼疮中风的发病机制、预防策略、管理方案、药物治疗及研究技术解析
Medicines (Basel). 2024 Jul 31;11(7):15. doi: 10.3390/medicines11070015.
3
The Emerging Specialty of Cardio-Rheumatology.心血管风湿病学：新兴亚专科
Curr Atheroscler Rep. 2024 Sep;26(9):499-509. doi: 10.1007/s11883-024-01221-7. Epub 2024 Jun 24.
本文引用的文献
1
Associations of Rheumatoid Factor, Rheumatoid Arthritis, and Interleukin-6 Inhibitor with the Prognosis of Ischemic Stroke: a Prospective Multicenter Cohort Study and Mendelian Randomization Analysis.类风湿因子、类风湿性关节炎和白细胞介素-6抑制剂与缺血性中风预后的关联：一项前瞻性多中心队列研究和孟德尔随机化分析
Transl Stroke Res. 2024 Aug;15(4):750-760. doi: 10.1007/s12975-023-01161-5. Epub 2023 May 31.
2
Safety of the JAK and TNF inhibitors in rheumatoid arthritis: real world data from the Hong Kong Biologics Registry.类风湿关节炎中 JAK 和 TNF 抑制剂的安全性：来自香港生物制剂注册处的真实世界数据。
Rheumatology (Oxford). 2024 Feb 1;63(2):358-365. doi: 10.1093/rheumatology/kead198.
3
Microglia activation in the presence of intact blood-brain barrier and disruption of hippocampal neurogenesis via IL-6 and IL-18 mediate early diffuse neuropsychiatric lupus.在血脑屏障完整的情况下，小胶质细胞被激活，IL-6 和 IL-18 破坏海马神经发生，介导早期弥漫性神经精神狼疮。
Ann Rheum Dis. 2023 May;82(5):646-657. doi: 10.1136/ard-2022-223506. Epub 2023 Mar 10.
4
Multibiomarker disease activity score: an objective tool for monitoring rheumatoid arthritis? A systematic review and meta-analysis.多生物标志物疾病活动评分：监测类风湿关节炎的客观工具？系统评价和荟萃分析。
Rheumatology (Oxford). 2023 Jun 1;62(6):2048-2059. doi: 10.1093/rheumatology/keac715.
5
Associations between Cardiovascular Outcomes and Rheumatoid Arthritis: A Nationwide Population-Based Cohort Study.心血管结局与类风湿关节炎之间的关联：一项基于全国人群的队列研究。
J Clin Med. 2022 Nov 17;11(22):6812. doi: 10.3390/jcm11226812.
6
Disease-modifying anti-rheumatic drugs improve the cardiovascular profile in patients with rheumatoid arthritis.改善病情抗风湿药物可改善类风湿关节炎患者的心血管状况。
Front Cardiovasc Med. 2022 Oct 24;9:1012661. doi: 10.3389/fcvm.2022.1012661. eCollection 2022.
7
Celecoxib and Etoricoxib may reduce risk of ischemic stroke in patients with rheumatoid arthritis: A nationwide retrospective cohort study.塞来昔布和依托考昔可能降低类风湿关节炎患者缺血性卒中风险：一项全国性回顾性队列研究。
Front Neurol. 2022 Oct 20;13:1018521. doi: 10.3389/fneur.2022.1018521. eCollection 2022.
8
The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritis.类风湿关节炎患者自身抗体与静脉血栓栓塞事件风险的相关性。
Rheumatology (Oxford). 2023 Jun 1;62(6):2106-2112. doi: 10.1093/rheumatology/keac601.
9
A comprehensive insight into effects of resveratrol on molecular mechanism in rheumatoid arthritis: A literature systematic review.深入了解白藜芦醇对类风湿关节炎分子机制影响的全面认识：文献系统综述。
Int J Rheum Dis. 2022 Aug;25(8):827-843. doi: 10.1111/1756-185X.14356. Epub 2022 Jun 27.
10
Effectiveness of TNF-inhibitors, abatacept, IL6-inhibitors and JAK-inhibitors in 31 846 patients with rheumatoid arthritis in 19 registers from the 'JAK-pot' collaboration.31846 例类风湿关节炎患者来自“JAK 抑制剂”合作研究的 19 个登记处，使用 TNF 抑制剂、阿巴西普、IL6 抑制剂和 JAK 抑制剂的疗效。
Ann Rheum Dis. 2022 Oct;81(10):1358-1366. doi: 10.1136/annrheumdis-2022-222586. Epub 2022 Jun 15.
Zotero 插件