Department of Hematology and Oncology, Walter Reed National Military Medical Center, Bethesda, Maryland.
Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Clin Adv Hematol Oncol. 2024 Jan-Feb;22(1):43-54.
Liquid biopsy is a test that allows for the diagnosis and analysis of cancer by sampling cancer cells or byproducts present in biological fluids such as blood or urine. It has the potential to create a new paradigm in oncologic care, being a less invasive approach than conventional tissue biopsy. Liquid biopsy has multifaceted applications for longitudinal disease monitoring in terms of surveillance, treatment response, and identification of emerging resistance mechanisms. Multiple assays currently exist or are in development for detecting circulating tumor cells, DNA, RNA, exosomes, proteins, fragmentomic markers, and metabolomes. Here, we review the applications of liquid biopsy in gastrointestinal cancers, emphasizing its use in both perioperative and advanced settings. We also examine its role in screening, diagnostics, and other cancer-related scenarios.
液体活检是一种通过采集癌症细胞或生物体液（如血液或尿液）中存在的代谢产物，来进行癌症诊断和分析的检测手段。它有潜力在肿瘤学治疗中创造一种新的范例，是一种比传统组织活检侵入性更小的方法。液体活检在疾病监测方面具有多方面的应用，包括监测、治疗反应以及识别新出现的耐药机制。目前有多种检测方法可用于检测循环肿瘤细胞、DNA、RNA、外泌体、蛋白质、片段组学标志物和代谢组学。在这里，我们综述了液体活检在胃肠道癌症中的应用，重点介绍了它在围手术期和晚期的应用。我们还研究了它在筛查、诊断和其他癌症相关场景中的作用。
