Saini Aman, Pershad Yash, Albadawi Hassan, Kuo Malia, Alzubaidi Sadeer, Naidu Sailendra, Knuttinen M-Grace, Oklu Rahmi
Division of Vascular and Interventional Radiology, Laboratory for Minimally Invasive Therapeutics, Mayo Clinic, Phoenix, AZ 85054, USA.
Diagnostics (Basel). 2018 Oct 29;8(4):75. doi: 10.3390/diagnostics8040075.
Liquid biopsy is the sampling of any biological fluid in an effort to enrich and analyze a tumor's genetic material. Peripheral blood remains the most studied liquid biopsy material, with circulating tumor cells (CTC's) and circulating tumor DNA (ctDNA) allowing the examination and longitudinal monitoring of a tumors genetic landscape. With applications in cancer screening, prognostic stratification, therapy selection and disease surveillance, liquid biopsy represents an exciting new paradigm in the field of cancer diagnostics and offers a less invasive and more comprehensive alternative to conventional tissue biopsy. Here, we examine liquid biopsies in gastrointestinal cancers, specifically colorectal, gastric, and pancreatic cancers, with an emphasis on applications in diagnostics, prognostics and therapeutics.
液体活检是对任何生物流体进行采样，以富集和分析肿瘤的遗传物质。外周血仍然是研究最多的液体活检材料，循环肿瘤细胞（CTC）和循环肿瘤DNA（ctDNA）可用于检查和纵向监测肿瘤的遗传图谱。液体活检在癌症筛查、预后分层、治疗选择和疾病监测中都有应用，代表了癌症诊断领域令人兴奋的新范例，并且提供了一种比传统组织活检侵入性更小、更全面的替代方法。在此，我们研究胃肠道癌症中的液体活检，特别是结直肠癌、胃癌和胰腺癌，重点关注其在诊断、预后和治疗方面的应用。
