Altern Ther Health Med. 2024 May;30(5):33-39.
To evaluate the effectiveness of Kangfuxin Liquid (a traditional Chinese medicine) gauze and Vaseline gauze in wound healing after necrotizing fasciitis surgery.
The study was conducted at The First Affiliated Hospital of Baotou Medical College between February 2020 and February 2022. A total of 54 patients diagnosed with necrotizing fasciitis were randomly assigned to the Vaseline gauze group as the control group, and the Kangfuxin Liquid gauze group as the experimental group. Various aspects of treatment efficacy, wound healing conditions, healing indicators, pain scores, inflammation markers, and adverse reactions were compared between the two groups.
The total effective rate in the experimental group (100.00%) was significantly higher than that in the control group (77.78%), with a statistically significant difference The experimental group showed lower scores for secretion, granulation tissue morphology, redness, and swelling compared to the control group, with statistical significance. Additionally, the experimental group exhibited faster slough separation, new epidermis formation, and overall wound healing compared to the control group, with statistical significance. Visual analog scale (VAS) scores on postoperative days 3, 7, 9, and 14 were significantly lower in the experimental group than in the control group. Before treatment, there was no statistically significant difference in the levels of interleukin-17 (IL-17), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) between the two groups. However, after treatment, both groups exhibited a decrease in inflammatory markers, and the experimental group had significantly lower levels of IL-17, IL-6, and TNF-α compared to the control group). Furthermore, the incidence of adverse reactions in the experimental group (3.70%) was significantly lower than that in the control group (22.22%).
The utilization of Kangfuxin Liquid gauze in wound healing after necrotizing fasciitis surgery effectively promotes wound healing, provides precise therapeutic effects, significantly reduces patient pain, improves inflammation, and exhibits minimal adverse reactions, thus demonstrating high safety. Therefore, the application of Kangfuxin Liquid gauze in this clinical context is highly recommended.
评价康复新液纱条与凡士林纱条在坏死性筋膜炎术后创面愈合中的应用效果。
本研究于 2020 年 2 月至 2022 年 2 月在包头医学院第一附属医院进行，将 54 例确诊为坏死性筋膜炎的患者随机分为凡士林纱条组（对照组）和康复新液纱条组（实验组）。比较两组患者的治疗效果、创面愈合情况、愈合指标、疼痛评分、炎症标志物及不良反应。
实验组总有效率（100.00%）明显高于对照组（77.78%），差异有统计学意义。实验组分泌物、肉芽组织形态、红肿、肿胀评分均低于对照组，差异有统计学意义。实验组创面腐脱、新皮形成及总体愈合时间均短于对照组，差异有统计学意义。实验组术后 3、7、9、14 天视觉模拟评分（VAS）均低于对照组，差异有统计学意义。治疗前，两组白细胞介素-17（IL-17）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平比较，差异无统计学意义；治疗后，两组炎症标志物均降低，且实验组 IL-17、IL-6、TNF-α水平低于对照组，差异有统计学意义。实验组不良反应发生率（3.70%）明显低于对照组（22.22%），差异有统计学意义。
康复新液纱条用于坏死性筋膜炎术后创面愈合中，可有效促进创面愈合，疗效确切，显著减轻患者疼痛，改善炎症反应，且不良反应发生率低，安全性高，推荐在临床中应用。
