祛瘀油纱外敷促进肛瘘患者术后愈合的临床研究

Clinical study of external application of Qiyu oil gauze for promoting post-operational healing in patients with anal fistula.

作者信息

Li Shao-tang, Cao Bo, Deng Wen-ling, Li Zhi

机构信息

Fujian Medical University, Fuzhou, 350004, China.

出版信息

Chin J Integr Med. 2009 Aug;15(4):279-83. doi: 10.1007/s11655-009-0279-5. Epub 2009 Aug 18.

DOI:10.1007/s11655-009-0279-5

PMID:19688316

Abstract

OBJECTIVE

To observe the effects of the external application of Qiyu oil gauze (QYOG) for promoting post-operational healing in patients with anal fistula and to explore its mechanism of action so as to provide a beneficial scientific basis for its wide use.

METHODS

Sixty patients with anal fistula scheduled to receive simple low anal fistulectomy were equally assigned, according to the sequence of hospitalization, to the tested group and the control group, and their wounds were classified according to longitudinal diameter into three grades (Grade I with a diameter below 2 cm; Grade II, 2-5 cm; and Grade III, over 5 cm). After the operation was completed and the operational wound was sterilized with benzalkonium bromide, the wound substratum was packed with QYOG in the test group and with vaseline gauze in the control group. The packing gauze was changed every day till the wound was healed. The healing time of the patients was observed, and the number of capillaries and positive cell percentages of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and epidermal growth factor (EGF) in wound granulation tissues were counted on the 5th day after the operation.

RESULTS

The wound healing time was 17.80+/-5.46 days in the test group, which was significantly shorter than that in the control group (21.90+/-6.32 days, P<0.01). The number of capillaries and positive cell percentages of VEGF and bFGF in wound granulation tissues on the 5th day in the tested group were higher than those in the control group (P<0.01), though the difference in EGF between the two groups was insignificant (P>0.05).

CONCLUSION

QYOG could shorten the wound healing time after anal fistulectomy, which suggests that it participates in the stimulation of wound granulation tissues to produce VEGF and bFGF, and thus promotes capillary genesis and improves blood circulation in wounds so as to promote wound healing.

摘要

目的

观察祛瘀油纱条（QYOG）外敷促进肛瘘患者术后创面愈合的效果，并探讨其作用机制，为其广泛应用提供有益的科学依据。

方法

将60例拟行单纯低位肛瘘切除术的肛瘘患者按住院顺序分为试验组和对照组，每组30例。根据创面纵径将其分为3级（Ⅰ级：直径<2 cm；Ⅱ级：直径2～5 cm；Ⅲ级：直径>5 cm）。手术完毕后，用苯扎溴铵对手术创面进行消毒，试验组创面基底填入QYOG，对照组填入凡士林纱条。每日更换填塞纱条，直至创面愈合。观察患者创面愈合时间，并于术后第5天计数创面肉芽组织中毛细血管数量及血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）、表皮生长因子（EGF）的阳性细胞百分率。