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B族链球菌菌株转化为稳定的细胞壁缺陷型变体后质粒介导抗性的丧失。

Loss of plasmid-mediated resistance after conversion of a group B streptococcus strain to a stable cell wall deficient variant.

作者信息

Schmitt-Slomska J, Caravano R, El-Solh N

出版信息

Ann Microbiol (Paris). 1979 Jan;130 A(1):23-7.

PMID:382949
Abstract

A group B streptococcus strain carrying plasmid DNA determining resistance to several drugs was converted by penicillin to cell wall (CW) defective and then to CW deficient variants (L-forms). The stable CW deficient variants became susceptible to antibiotics in study. Dye-buoyant density analysis of the DNA of CW deficient variants showed that the loss of antibiotic resistance was associated with the loss of extrachromosomal DNA.

摘要

一株携带决定对多种药物耐药性的质粒DNA的B组链球菌菌株,经青霉素处理后转变为细胞壁(CW)缺陷型,进而转变为CW缺失变体(L型)。稳定的CW缺失变体在研究中变得对抗生素敏感。对CW缺失变体的DNA进行染料浮力密度分析表明,抗生素耐药性的丧失与染色体外DNA的丢失有关。

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