Key Laboratory of Molecular Biophysics of Ministry of Education, Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
College of Life Science, Henan Agricultural University, Zhengzhou, Henan, China.
Cell Rep. 2024 Feb 27;43(2):113708. doi: 10.1016/j.celrep.2024.113708. Epub 2024 Jan 31.
Organisms sensing environmental cues and internal states and integrating the sensory information to control fecundity are essential for survival and proliferation. The present study finds that a moderate cold temperature of 11°C reduces egg laying in Caenorhabditis elegans. ASEL and AWC neurons sense the cold via GCY-20 signaling and act antagonistically on egg laying through the ASEL and AWC/AIA/HSN circuits. Upon cold stimulation, ASEL and AWC release glutamate to activate and inhibit AIA interneurons by acting on highly and lowly sensitive ionotropic GLR-2 and GLC-3 receptors, respectively. AIA inhibits HSN motor neuron activity via acetylcholinergic ACR-14 receptor signaling and suppresses egg laying. Thus, ASEL and AWC initiate and reduce the cold suppression of egg laying. ASEL's action on AIA and egg laying dominates AWC's action. The biased opposite actions of these neurons on egg laying provide animals with a precise adaptation of reproductive behavior to environmental temperatures.
生物感知环境线索和内部状态，并整合感官信息来控制生殖能力，这对生存和繁殖至关重要。本研究发现，中等寒冷温度 11°C 会减少秀丽隐杆线虫的产卵。ASEL 和 AWC 神经元通过 GCY-20 信号感知寒冷，并通过 ASEL 和 AWC/AIA/HSN 回路拮抗作用控制产卵。在寒冷刺激下，ASEL 和 AWC 释放谷氨酸，分别通过作用于高敏和低敏离子型 GLR-2 和 GLC-3 受体，激活并抑制 AIA 中间神经元。AIA 通过乙酰胆碱能 ACR-14 受体信号抑制 HSN 运动神经元活动并抑制产卵。因此，ASEL 和 AWC 启动并减少了寒冷对产卵的抑制。ASEL 对 AIA 和产卵的作用超过了 AWC。这些神经元对产卵的偏向相反作用使动物能够精确地适应生殖行为以适应环境温度。
