College of Basic Medical Sciences, Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, Jilin, China.
Radiation Medicine, School of Public Health, Jilin University, Changchun 130021, Jilin, China.
Int J Biol Macromol. 2024 Mar;261(Pt 2):129799. doi: 10.1016/j.ijbiomac.2024.129799. Epub 2024 Feb 1.
With the extensive use of antibiotics, resulting in increasingly serious problems of bacterial resistance, antimicrobial therapy has become a global concern. Metal-organic frameworks (MOFs) are low-density porous coordination materials composed of metal ions and organic ligands, which can form composite materials with biomacromolecules such as proteins and polysaccharides. In recent years, MOFs and their derivatives have been widely used in the antibacterial field as efficient antibacterial agents. This review offers a detailed summary of the antibacterial applications of MOFs and their composites, and the different synthesis methods and antibacterial mechanisms of MOFs and MOF-based composites are briefly introduced. Finally, the challenges and prospects of MOFs-based antibacterial materials in the rapidly developing medical field were briefly discussed. We hope this review will provide new strategies for the medical application of MOFs-based antibacterial materials.
随着抗生素的广泛使用，导致细菌耐药性问题日益严重，抗菌治疗已成为全球关注的焦点。金属-有机框架（MOFs）是由金属离子和有机配体组成的低密度多孔配位材料，可与蛋白质和多糖等生物大分子形成复合材料。近年来，MOFs 及其衍生物已广泛应用于抗菌领域，作为高效抗菌剂。本文详细总结了 MOFs 及其复合材料的抗菌应用，并简要介绍了 MOFs 和 MOF 基复合材料的不同合成方法和抗菌机制。最后，简要讨论了基于 MOFs 的抗菌材料在快速发展的医疗领域所面临的挑战和前景。我们希望本文的综述将为基于 MOFs 的抗菌材料的医学应用提供新的策略。
