State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, PR China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, PR China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210029, PR China.
Fitoterapia. 2024 Apr;174:105840. doi: 10.1016/j.fitote.2024.105840. Epub 2024 Jan 29.
The phytochemical investigation of the aerial parts of Isodon japonica var. glaucocalyx afforded four undescribed (glaucocalyxin O-R, 1-4) and six known ent-kauranoids (5-10). Their structures were established using NMR and MS measurements. Compounds 1 and 2 are dimeric ent-kaurane-type diterpenoids. Moreover, the plausible biogenetic pathways for compounds 1 and 2 were proposed as Michael addition between two monomers. Eight compounds were assayed for their anti-inflammatory activity by evaluating NO production in LPS-induced RAW 267.4 cells, and compounds 7, 8 and 9 exhibited relatively remarkable anti-inflammatory activities at 10 μM.
对蓝萼香茶菜地上部分的植物化学研究得到了四个未描述的（蓝萼香茶菜素 O-R，1-4）和六个已知的 ent-贝壳杉烷类化合物（5-10）。它们的结构是通过 NMR 和 MS 测量确定的。化合物 1 和 2 是二聚体 ent-贝壳杉烷型二萜类化合物。此外，还提出了化合物 1 和 2 的可能生物合成途径，即两个单体之间的迈克尔加成。通过评估 LPS 诱导的 RAW 267.4 细胞中 NO 产生，对 8 种化合物进行了抗炎活性测试，化合物 7、8 和 9 在 10 μM 时表现出相对显著的抗炎活性。
